Glechoma hederacea inhibits inflammatory mediator release in IFN-gamma and LPS-stimulated mouse peritoneal macrophages

Journal of Ethnopharmacology
Hyo-Jin AnSeung-Heon Hong

Abstract

Glechoma hederacea (GH) is an herb widely used herb medicine for the treatment of a variety of pathologies. In this study, the effect of GH on interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS)-induced production of nitric oxide (NO), interleukin (IL)-12p70, IL-12p40, tumor necrosis factor-alpha (TNF-alpha), and IL-6 were examined using mouse peritoneal macrophages. GH inhibits IFN-gamma/LPS-induced NO in a dose-dependent manner. The decrease in NO synthesis was reflected as a decreased amount of inducible NO synthase protein. We also found that GH inhibits pro-inflammatory cytokine, IL-12p70, and TNF-alpha production. However, GH increased IFN-gamma/LPS-induced IL-12p40 production. GH doesn't affect the IL-6 production. These findings mean that GH can be used in controlling macrophages mediated inflammation related disease.

References

Jan 1, 1984·Annual Review of Immunology·D O Adams, T A Hamilton
Jan 1, 1994·Cardiovascular Research·A PetrosP Vallance
Jan 1, 1993·Agents and Actions·N K Boughton-SmithS Moncada
Dec 18, 2001·Journal of Ethnopharmacology·B H BabuJ Padikkala
Mar 22, 2002·Nature Reviews. Immunology·John J O'SheaPeter Lipsky
May 3, 2002·The New England Journal of Medicine·Jennifer D GormanJohn C Davis
Sep 17, 2002·Biological & Pharmaceutical Bulletin·Hwan-Suck ChungHyung-Min Kim
Nov 13, 2002·Current Rheumatology Reports·Christopher T Ritchlin
Dec 20, 2002·Fitoterapia·Y KumarasamyS D Sarker
Oct 18, 2003·Cytokine & Growth Factor Reviews·Peter J Barnes
Oct 22, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hyun-Ja JeongHyung-Min Kim
Jun 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qiming ChenG Mark Anderson

❮ Previous
Next ❯

Citations

Feb 20, 2013·Journal of Asian Natural Products Research·Qiu-Fang ZhuHai-Bin Qu
Oct 23, 2012·International Journal of Biological Macromolecules·Biswajit DeySyed S Islam
May 23, 2014·Journal of Dental Research·J K HwangM S Kim
Jun 2, 2018·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Cristina M UrituBogdan I Tamba
Jan 20, 2021·Journal of Ethnopharmacology·Ying ZhouXiao-Dong Luo
Jul 16, 2021·BMC Complementary Medicine and Therapies·Min XiaoZhong Zuo
Aug 5, 2021·Current Research in Toxicology·Somesh BanerjeePartha Roy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.