Glia-related genes and their contribution to schizophrenia

Psychiatry and Clinical Neurosciences
Chenyao WangNorio Ozaki

Abstract

Schizophrenia, a debilitating disease with 1% prevalence in the general population, is characterized by major neuropsychiatric symptoms, including delusions, hallucinations, and deficits in emotional and social behavior. Previous studies have directed their investigations on the mechanism of schizophrenia towards neuronal dysfunction and have defined schizophrenia as a 'neuron-centric' disorder. However, along with the development of genetics and systematic biology approaches in recent years, the crucial role of glial cells in the brain has also been shown to contribute to the etiopathology of schizophrenia. Here, we summarize comprehensive data that support the involvement of glial cells (including oligodendrocytes, astrocytes, and microglial cells) in schizophrenia and list several acknowledged glia-related genes or molecules associated with schizophrenia. Instead of purely an abnormality of neurons in schizophrenia, an additional 'glial perspective' provides us a novel and promising insight into the causal mechanisms and treatment for this disease.

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Citations

Sep 2, 2016·Frontiers in Cellular Neuroscience·Ana Cathia Magalhães, Claudio Rivera
Mar 3, 2020·Frontiers in Pharmacology·Vadim V TarasovGjumrakch Aliev
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Feb 12, 2021·International Journal of Molecular Sciences·Baiyan Ren, Anna Dunaevsky
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Jun 1, 2021·Current Opinion in Immunology·Weronika BarcikFrancesco Papaleo
Oct 16, 2021·Translational Psychiatry·Caitlin E MurphyCynthia Shannon Weickert

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