PMID: 7543212Jul 1, 1995Paper

Gliadin-specific T cell responses in peripheral blood of healthy individuals involve T cells restricted by the coeliac disease associated DQ2 heterodimer

Scandinavian Journal of Immunology
K JensenK E Lundin

Abstract

Coeliac disease (CD) is probably caused by an abnormal immune response towards wheat gliadin in the small intestine. We found that gliadin-specific T cells from the small intestinal mucosa of HLA-DQ2 positive CD patients were almost exclusively restricted by the disease-associated DQ2 molecule. In the peripheral blood of CD patients, a large proportion of gliadin-specific T cells were found to be restricted by DQ molecules, including DQ2, but many were instead restricted by DR or DP molecules of the patient. We have now investigated gliadin-specific T cell responses in peripheral blood from healthy individuals. Four of 20 persons tested had strong in vitro responses and were used as donors for gliadin-specific T cell clones. We found gliadin-specific T cells restricted by the CD-associated DQ2 molecule in peripheral blood for two of these four individuals. It is the presence of such T cells also in the small intestinal mucosa which seems typical of CD.

References

Dec 12, 1991·The New England Journal of Medicine·J S Trier
Jan 1, 1989·The Journal of Experimental Medicine·L M SollidE Thorsby
Sep 1, 1994·Human Immunology·K E LundinE Thorsby

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Citations

May 7, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·K E A Lundin
Feb 19, 1998·Scandinavian Journal of Immunology·P KlemettiO Vaarala
Aug 9, 2003·Lancet·Peter H R Green, Bana Jabri
Aug 19, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ross ComerfordConleth Feighery
Mar 16, 2007·Digestive Diseases and Sciences·Eduardo Garcia VilelaAloíso Sales da Cunha
Jul 18, 2015·Nutrients·Itziar ChurrucaEdurne Simon
Mar 13, 2013·Current Opinion in Immunology·Robert P Anderson, Bana Jabri
Feb 24, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M MirabellaA P Batocchi
Jul 11, 2012·Clinical and Experimental Immunology·A CamarcaC Gianfrani
Sep 25, 2004·Muscle & Nerve·Kleopas A KleopaTheodoros Kyriakides
Jan 28, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Matthias WittstockReiner Benecke
Jul 29, 2005·Immunological Reviews·Bana JabriPeter H R Green
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kay E BlackChella S David

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