Glial activation and inflammation along the Alzheimer's disease continuum

Journal of Neuroinflammation
Kaja NordengenTormod Fladby

Abstract

Neuronal and glial cell interaction is essential for synaptic homeostasis and may be affected in Alzheimer's disease (AD). We measured cerebrospinal fluid (CSF) neuronal and glia markers along the AD continuum, to reveal putative protective or harmful stage-dependent patterns of activation. We included healthy controls (n = 36) and Aβ-positive (Aβ+) cases (as defined by pathological CSF amyloid beta 1-42 (Aβ42)) with either subjective cognitive decline (SCD, n = 19), mild cognitive impairment (MCI, n = 39), or AD dementia (n = 27). The following CSF markers were measured: a microglial activation marker-soluble triggering receptor expressed on myeloid cells 2 (sTREM2), a marker of microglial inflammatory reaction-monocyte chemoattractant protein-1 (MCP-1), two astroglial activation markers-chitinase-3-like protein 1 (YKL-40) and clusterin, a neuron-microglia communication marker-fractalkine, and the CSF AD biomarkers (Aβ42, phosphorylated tau (P-tau), total tau (T-tau)). Using ANOVA with planned comparisons, or Kruskal-Wallis tests with Dunn's pairwise comparisons, CSF levels were compared between clinical groups and between stages of biomarker severity using CSF biomarkers for classification based on amyloid pathology (A), tau ...Continue Reading

References

Jun 5, 1990·Biochemistry·H V de SilvaJ Robbins
Jun 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·C P HughesR L Martin
Aug 8, 1993·The Journal of Comparative Neurology·M DanikR Quirion
Apr 1, 1993·Journal of Neurobiology·M K O'BryanM J Pearse
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·J K HarrisonL Feng
May 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A BouchonM Colonna
Jul 10, 2003·Brain Research·Tetsuya MizunoAkio Suzumura
Oct 10, 2003·Journal of Neuropathology and Experimental Neurology·Sandra HulshofKnut Biber
Oct 16, 2003·Brain Research. Molecular Brain Research·Maja PuchadesPia Davidsson
Feb 25, 2005·The Journal of Experimental Medicine·Kazuya TakahashiHarald Neumann
Oct 26, 2005·Dementia and Geriatric Cognitive Disorders·Imrich BlaskoChristian Humpel
Dec 21, 2005·Neuron·John R CirritoDavid M Holtzman
Apr 12, 2006·Archives of Neurology·Daniela GalimbertiElio Scarpini
Jul 16, 2008·Neuroscience·Y CharnayP Giannakopoulos
Aug 15, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Suzanne E HickmanJoseph El Khoury
Mar 12, 2009·CNS & Neurological Disorders Drug Targets·Dave Morgan
Apr 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shweta MandrekarGary E Landreth
May 16, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Satish L DeshmaneBassel E Sawaya
Jan 5, 2011·Acta Neurologica Scandinavica·M SotaniemiT Hänninen
Jan 27, 2011·Journal of Neuroinflammation·Mibel M PabonPaula C Bickford
Jan 26, 2012·Molecular Neurobiology·Jin-Tai Yu, Lan Tan
Oct 17, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Per SelnesTormod Fladby
Nov 16, 2012·The New England Journal of Medicine·Thorlakur JonssonKari Stefansson
Nov 16, 2012·The New England Journal of Medicine·Rita GuerreiroUNKNOWN Alzheimer Genetic Analysis Group
Dec 20, 2013·Neuroscience Bulletin·Xiang LiZhongxin Zhao
Jan 1, 2014·JAMA Neurology·Rahul S DesikanUNKNOWN Alzheimer’s Disease Neuroimaging Initiative Group
Mar 7, 2014·Science Translational Medicine·Anne M FaganUNKNOWN Dominantly Inherited Alzheimer Network
May 7, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Frank JessenUNKNOWN Subjective Cognitive Decline Initiative (SCD-I) Working Group
Jul 6, 2014·Science Translational Medicine·Gernot KleinbergerChristian Haass
Jul 16, 2014·Journal of Alzheimer's Disease : JAD·Anna AntonellJosé Luis Molinuevo
Jul 23, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Teng JiangJin-Tai Yu

❮ Previous
Next ❯

Citations

Nov 2, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Anna AntonellRaquel Sánchez-Valle
Mar 19, 2020·Expert Review of Proteomics·Jong-Heon KimKyoungho Suk
Feb 12, 2020·Reviews in the Neurosciences·Valentin DichevVictoria Sarafian
Jan 4, 2020·Therapeutic Advances in Neurological Disorders·Marta Milà-AlomàJosé Luís Molinuevo
Jul 9, 2020·Journal of Neuroinflammation·Jiaolong YangZhentao Zhang
Jul 18, 2020·Journal of Alzheimer's Disease : JAD·Kristen R HollingerBarbara S Slusher
Aug 10, 2019·BioMed Research International·Henriette R FrederiksenKristine Freude
Jun 23, 2020·Journal of Alzheimer's Disease : JAD·Steinunn ThordardottirCaroline Graff
Jun 17, 2020·Frontiers in Neurology·Nayana GaurJulian Grosskreutz
Dec 5, 2019·Frontiers in Pharmacology·Paula Maria Quaglio BelloziAntônio Carlos Pinheiro de Oliveira
Sep 22, 2020·Brain Communications·Alireza FaridarStanley H Appel
Apr 15, 2020·Experimental & Molecular Medicine·Sun Ah ParkChae Eun Kim
Jan 17, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael Fossel
Aug 18, 2020·Molecular Neurobiology·Thura Tun OoSiriporn C Chattipakorn
Apr 17, 2020·Frontiers in Immunology·Harald HampelSimone Lista
Jun 15, 2019·Expert Review of Proteomics·Filippo BaldacciHarald Hampel
Oct 20, 2020·Journal of Immunotoxicology·Thitima KasemsukPornpun Vivithanaporn
Jan 23, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Jordan BryanUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Dec 16, 2019·Current Opinion in Neurobiology·Joel SimrénHenrik Zetterberg
Feb 14, 2021·Brain Sciences·Donovan A McGrowderRuby Alexander-Lindo
Nov 12, 2020·Frontiers in Aging Neuroscience·Katie MayneAlerie G de la Fuente
Nov 15, 2020·Journal of Personalized Medicine·Eleonora Del PreteFilippo Baldacci
Dec 18, 2020·Frontiers in Aging Neuroscience·Season K Wyatt-Johnson, Randy R Brutkiewicz
Nov 17, 2020·Brain, Behavior, and Immunity·Anne-Laure Hemonnot-GirardHelene Hirbec
Nov 1, 2020·Trends in Pharmacological Sciences·Lorenzo GaetaniLucilla Parnetti
Mar 7, 2021·Clocks & Sleep·Rachel Van Drunen, Kristin Eckel-Mahan
Mar 9, 2021·BMJ Neurology Open·Gianluigi Forloni
Mar 14, 2021·Molecular Neurobiology·Peng-Fei ZhangJin-Tai Yu
Apr 27, 2021·Metabolic Brain Disease·John ZhouMd Golam Sharoar
May 14, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·David G Morgan, Michelle M Mielke
Jun 3, 2021·Cells·Melissa K EdlerJason R Richardson

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assays
ELISA

Software Mentioned

BIOMARKAPD
Statistical Package for Social Sciences ( SPSS )

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.