Glial and neuronal functions of the Drosophila homolog of the human SWI/SNF gene ATR-X (DATR-X) and the jing zinc-finger gene specify the lateral positioning of longitudinal glia and axons.

Genetics
Xuetao SunMargaret J Sonnenfeld

Abstract

Neuronal-glial communication is essential for constructing the orthogonal axon scaffold in the developing Drosophila central nervous system (CNS). Longitudinal glia (LG) guide extending commissural and longitudinal axons while pioneer and commissural neurons maintain glial survival and positioning. However, the transcriptional regulatory mechanisms controlling these processes are not known. Previous studies showed that the midline function of the jing C2H2-type zinc-finger transcription factor was only partially required for axon scaffold formation in the Drosophila CNS. We therefore screened for gain-of-function enhancers of jing gain of function in the eye and identified the Drosophila homolog of the disease gene of human alpha-thalassemia/mental retardation X-linked (ATR-X) as well as other genes with potential roles in gene expression, translation, synaptic transmission, and cell cycle. jing and DATR-X reporter genes are expressed in both CNS neurons and glia, including the LG. Coexpression of jing and DATR-X in embryonic neurons synergistically affects longitudinal connective formation. During embryogenesis, jing and DATR-X have autonomous and nonautonomous roles in the lateral positioning of LG, neurons, and longitudinal ...Continue Reading

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Citations

Nov 10, 2010·Development Genes and Evolution·Margaret SonnenfeldXuetao Sun
May 8, 2008·PloS One·Andrew R BassettAndrew A Travers
May 2, 2009·Biochemical and Biophysical Research Communications·Yoon Ki HongKyoung Sang Cho
Dec 1, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Zhao-Ying DingMin-Lang Huang
Mar 5, 2013·Current Biology : CB·Saad ArifAlistair P McGregor
May 18, 2016·Journal of Molecular and Cellular Cardiology·Dimitry A ChistiakovYuri V Bobryshev
Dec 18, 2008·Human Molecular Genetics·Chantal F MedinaDavid J Picketts
Feb 26, 2019·Proceedings of the National Academy of Sciences of the United States of America·Smita YadavYuh Nung Jan
Jun 13, 2015·Genes & Development·Hyuckjoon KangMitzi I Kuroda

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