PMID: 8989660Jan 1, 1997Paper

Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor for sensory neurons: comparison with the effects of the neurotrophins

Journal of Neurobiology
C R MathesonQ Yan

Abstract

We compared the effects of glial cell line-derived neurotrophic factor (GDNF) on dorsal root ganglion (DRG) sensory neurons to that of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 (NT-3). All of these factors were retrogradely transported to subpopulations of sensory neuron cell bodies in the L4/ L5 DRG of neonatal rats. The size distribution of 125I-GDNF-labeled neurons was variable and consisted of both small and large DRG neurons (mean of 506.60 microns2). 125I-NGF was preferentially taken up by small neurons with a mean cross-sectional area of 383.03 microns2. Iodinated BDNF and NT-3 were transported by medium to large neurons with mean sizes of 501.48 and 529.27 microns2, respectively. A neonatal, sciatic nerve axotomy-induced cell death model was used to determine whether any of these factors could influence DRG neuron survival in vivo. GDNF and NGF rescued nearly 100% of the sensory neurons. BDNF and NT-3 did not promote any detectable level of neuronal survival despite the fact that they underwent retrograde transport. We examined the in vitro survival-promoting ability of these factors on neonatal DRG neuronal cultures derived from neonatal rats. GDNF, NGF, and NT-3 were effec...Continue Reading

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Citations

Nov 1, 2001·Brain Research. Molecular Brain Research·H KashibaE Senba
Feb 13, 1999·Progress in Neurobiology·M J Millan
Nov 17, 1999·The European Journal of Neuroscience·I GavazziJ Cohen
Mar 12, 2002·The European Journal of Neuroscience·Eric G FinePatrick Aebischer
Jun 8, 2000·Annals of the New York Academy of Sciences·R KuangE Magal
Aug 24, 2012·Journal of Neurophysiology·Pedro AlvarezJon D Levine
Oct 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jens StrelauKlaus Unsicker
Mar 20, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Judith P GoldenSanjay Jain
Dec 17, 2008·Neurological Research·Andrew M HartMikael Wiberg
Dec 20, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Srinivas Madduri, Bruno Gander
May 10, 2008·Journal of Biomedical Materials Research. Part a·Matthew D WoodShelly E Sakiyama-Elbert
Sep 29, 2006·Journal of Anatomy·Paul J Kingham, Giorgio Terenghi
Jan 14, 2010·Developmental Biology·Teresa Valdés-SánchezIsabel Fariñas
Mar 4, 2006·Neuroscience Letters·Megumi AitaTakeyasu Maeda
Feb 15, 2007·Expert Opinion on Therapeutic Targets·Birgit T Priest, Gregory J Kaczorowski
Jan 11, 2001·Developmental Biology·H M YoungD F Newgreen
Jan 30, 2008·Free Radical Biology & Medicine·Y H ChouA M Y Lin
Dec 12, 2001·Molecular Therapy : the Journal of the American Society of Gene Therapy·L H McGee SanftnerJ G Flannery
May 10, 2017·Biotechnology and Bioengineering·Xueping EeMatthew D Wood
Jun 16, 2009·Neuroscience Research·Srinivas MadduriBruno Gander

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