PMID: 9633807Jun 20, 1998Paper

Glial cell responses, complement, and clusterin in the central nervous system following dorsal root transection

Glia
L LiuH Aldskogius

Abstract

We have examined the glial cell response, the possible expression of compounds associated with the complement cascade, including the putative complement inhibitor clusterin, and their cellular association during Wallerian degeneration in the central nervous system. Examination of the proliferation pattern revealed an overall greater mitotic activity after rhizotomy, an exclusive involvement of microglia in this proliferation after peripheral nerve injury, but, in addition, a small fraction of proliferating astrocytes after rhizotomy. Immunostaining with the phagocytic cell marker ED1 gradually became very prominent after rhizotomy, possibly reflecting a response to the extensive nerve fiber disintegration. Lumbar dorsal rhizotomy did not induce endogenous immunoglobulin G (IgG) deposition or complement expression in the spinal cord dorsal horn, dorsal funiculus, or gracile nucleus. This is in marked contrast to the situation after peripheral nerve injury, which appears to activate the entire complement cascade in the vicinity of the central sensory processes. Clusterin, a multifunctional protein with complement inhibitory effects, was markedly upregulated in the dorsal funiculus in astrocytes. In addition, there was an intense ...Continue Reading

Citations

Aug 31, 2001·Microscopy Research and Technique·H Aldskogius
Jun 13, 2006·Cellular and Molecular Neurobiology·Zhenlian MaShaojun Liu
May 21, 2005·Journal of Neuroimmunology·Zhiren ZhangHermann J Schluesener
Feb 19, 2003·Brain Research. Brain Research Reviews·Håkan Aldskogius, Elena N Kozlova
May 26, 1999·Progress in Neurobiology·G Stoll, S Jander
Jan 5, 2002·Journal of Physiology, Paris·J V PriestleyR A Brown
Dec 11, 2003·Molecular and Cellular Neurosciences·Susna DeSamuel David
Oct 28, 2003·Journal of Neurotrauma·Marcus OhlssonMikael Svensson
Feb 3, 2005·Journal of Neurotrauma·Aileen J AndersonCarl W Cotman
Sep 18, 2008·Neuroreport·Grzegorz WicherHakan Aldskogius
Jan 19, 2005·The European Journal of Neuroscience·Lowell T McPhailMatt S Ramer
Mar 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mei XuCharles Chavkin
Apr 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Johnna DohertyMarc R Freeman
Dec 1, 2009·Neurosurgery Clinics of North America·Gurvinder KaurCourtney Crane
Nov 21, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Isaac YangAndrew T Parsa
Aug 2, 2008·Molecular Immunology·V RamagliaF Baas
May 5, 2005·The European Journal of Neuroscience·Grzegorz K Wicher, Håkan Aldskogius
Nov 16, 2007·The European Journal of Neuroscience·Mani VessalCorinna Darian-Smith
Feb 16, 2005·Journal of Neuroimmunology·Thomas BeiterHermann J Schluesener
Aug 17, 2006·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jeremy S TomaMatt S Ramer
Nov 18, 2005·Neuroscience Letters·Marcus Ohlsson, Leif A Havton
May 7, 2013·Brain, Behavior, and Immunity·Katja SchmitzIrmgard Tegeder
May 1, 1999·Experimental Neurology·L LiuH Aldskogius
Jan 24, 2003·Expert Opinion on Therapeutic Targets·Håkan Aldskogius

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