PMID: 8835785Jun 1, 1996Paper

Glial cells in transected optic nerves of immature rats. I. An analysis of individual cells by intracellular dye-injection

Journal of Neurocytology
A M Butt, K Colquhoun

Abstract

The glial response to Wallerian degeneration was studied in optic nerves following unilateral enucleation in immature rats, aged 21 days old (P21). The three-dimensional morphology of dye-filled glia was determined in intact nerves, at post-enucleation day 21 in normal nerves from untreated P21 rats, by correlating laser scanning confocal microscopy and camera lucida drawings of single cells. In normal and transected nerves, the majority of dye-filled cells comprized astrocytes (54% and 65%, respectively). In normal P21 nerves, the predominant astrocyte form had a complex stellate morphology and had a centrally-located cell body from which branching processes extended randomly. Two other distinct forms were transverse and longitudinal astrocytes, which had a polarized process extension in a plane perpendicular or parallel to the long axis of the nerve, respectively. These forms were recognized in transected nerves also, but astrocytes in transected nerves had a simple morphology on the whole, and extended few, dense processes which branched infrequently. Quantitative analysis of astrocyte morphology confirmed that individual astrocytes underwent considerable remodelling in response to Wallerian degeneration. A prominent reactio...Continue Reading

References

Jun 15, 1975·The Journal of Comparative Neurology·R P Skoff
Jan 1, 1990·Acta Neuropathologica·S K Ludwin
Jun 15, 1990·The Journal of Comparative Neurology·P A Trimmer, R E Wunderlich
Jan 1, 1990·Acta Neuropathologica·S K Ludwin
Feb 18, 1985·Brain Research·A J Mathewson, M Berry
Jan 1, 1969·The Journal of Comparative Neurology·S Mori, C P Leblond
Oct 1, 1970·The Journal of Comparative Neurology·J E VaughnR P Skoff
Sep 20, 1983·The Journal of Comparative Neurology·V H PerryR Linden
Jan 1, 1981·Journal of Neuropathology and Experimental Neurology·A PrivatJ Fulcrand
Mar 1, 1995·Trends in Neurosciences·R J Franklin, W F Blakemore
Dec 1, 1993·The Journal of Comparative Neurology·A M Butt, B R Ransom
Dec 1, 1995·Journal of Neurocytology·M BerryA M Butt
Mar 1, 1989·The European Journal of Neuroscience·Robert H. MillerMartin C. Raff
Oct 1, 1958·The Journal of Comparative Neurology·E RAMON-MOLINER

❮ Previous
Next ❯

Citations

Mar 31, 2005·Molecular and Cellular Neurosciences·Daniel S Heffron, James W Mandell
Oct 11, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Daniel Sun, Tatjana C Jakobs
Oct 22, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel SunTatjana C Jakobs
Feb 11, 1998·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·T Tanabe, I Okutsu
May 15, 2004·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·A Yoshida, I Okutsu
Apr 3, 2001·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·I OkutsuK Sugiyama
Aug 21, 2019·Glia·Carole EscartinMaria-Angeles Carrillo-de Sauvage

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.