Glial cells modulate heparan sulfate proteoglycan (HSPG) expression by neuronal precursors during early postnatal cerebellar development

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Ana Paula B AraujoMarimélia A Porcionatto

Abstract

Cerebellum controls motor coordination, balance, eye movement, and has been implicated in memory and addiction. As in other parts of the CNS, correct embryonic and postnatal development of the cerebellum is crucial for adequate performance in the adult. Cellular and molecular defects during cerebellar development can lead to severe phenotypes, such as ataxias and tumors. Knowing how the correct development occurs can shed light into the mechanisms of disease. Heparan sulfate proteoglycans are complex molecules present in every higher eukaryotic cells and changes in their level of expression as well as in their structure lead to drastic functional alterations. This work aimed to investigate changes in heparan sulfate proteoglycans expression during cerebellar development that could unveil control mechanisms. Using real time RT-PCR we evaluated the expression of syndecans, glypicans and modifying enzymes by isolated cerebellar granule cell precursors, and studied the influence of soluble glial factors on the expression of those genes. We evaluated the possible involvement of Runx transcription factors in the response of granule cell precursors to glial factors. Our data show for the first time that cerebellar granule cell precurs...Continue Reading

References

Apr 1, 1990·Biochemical Society Transactions·J T GallagherM Lyon
Feb 1, 1996·The Histochemical Journal·N MiosgeR Herken
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Sep 25, 2002·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Stephan Kröger, Jörn E Schröder
Sep 28, 2002·Nature Neuroscience·Ken-ichi InoueYoshiaki Ito
Jan 7, 2003·IUBMB Life·Kazuyuki Sugahara, Hiroshi Kitagawa
May 23, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Miriam Ford-PerrissMark Murphy
Sep 17, 2003·Glycoconjugate Journal·Valerie A WilsonCatherine L R Merry
Apr 24, 2004·Critical Reviews in Eukaryotic Gene Expression·Jane B LianGary S Stein
Apr 28, 2004·Cellular and Molecular Life Sciences : CMLS·L-A FranssonS Sandgren
May 25, 2004·Oncogene·Kristie L Durst, Scott W Hiebert
Jul 19, 2005·Annual Review of Neuroscience·Mary E Hatten, Nathaniel Heintz
Feb 28, 2006·Biochemical and Biophysical Research Communications·M KnippenbergJ Klein-Nulend
Feb 28, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M A Porcionatto
Jan 16, 2007·Current Opinion in Neurobiology·Sarah A Busch, Jerry Silver
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Toshihisa Komori
Jul 8, 2008·Neural Networks : the Official Journal of the International Neural Network Society·Akira SatoTeiichi Furuichi
Aug 30, 2008·Neural Development·Ken-ichi InoueYoshiaki Ito
Aug 30, 2008·The International Journal of Biochemistry & Cell Biology·Hourinaz Behesti, Silvia Marino
Oct 9, 2008·Current Opinion in Oncology·Alberto GulinoFelice Giangaspero
Dec 6, 2008·The Cerebellum·Maja Steinlin
Feb 19, 2009·The Cerebellum·Catherine Vaillant, Denis Monard
Mar 17, 2009·Nature Neuroscience·Jennifer A ChanRosalind A Segal
Oct 9, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anna Lisa LucidoDavid R Colman

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Citations

May 21, 2016·Frontiers in Cellular Neuroscience·Ana P B AraujoFlávia C A Gomes
Jun 21, 2019·The Cerebellum·Ana Paula Bergamo AraujoFlávia Carvalho Alcantara Gomes

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