Jun 24, 1996

Glial-derived neurotrophic factor (GDNF) induced morphological differentiation of an immortalized monoclonal hybrid dopaminergic cell line of mesencephalic neuronal origin

Brain Research
Alfred HellerLisa Won

Abstract

Monoclonal hybrid cell lines derived from either mesencephalic or striatal neuronal parents were screened for the effects of glial-derived neurotrophic factor (GDNF) on morphological differentiation. The mesencephalic dopaminergic MN9D cell line responded to GDNF with a 3- to 4-fold increase in the number of differentiated solitary cells and provides an unlimited source of monoclonal cells for studies on the mechanism of action of GDNF and the nature of its receptor.

Mentioned in this Paper

GDNF gene
Neurotrophic factor
Immortalization
Neuroglia
Cell Hybridization
Cell Differentiation Process
Neurite Outgrowth Factors
Neuronal
Hybrid Cells
Midbrain Structure

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