Abstract
Glial-derived neurotropic factor (GDNF) signaling is mediated through a 2-component system consisting of the so-called GDNF receptor-alpha (GFRalpha1), which binds to GDNF. This complex activates the tyrosine kinase receptor RET. In this paper we demonstrate GDNF, GFRalpha1, and RET mRNA and protein expression in the human anterior pituitary gland. Double immunohistochemistry of anterior pituitary sections showed GDNF immunoreactivity in more than 95% of somatotrophs and to a lesser extent in corticotrophs (20%); it was almost absent in the remaining cell types. Also, although more than 95% of somatotrophs were stained for RET, no positive immunostaining could be detected in other cell types. Furthermore, we have looked for GDNF and RET in human pituitary adenomas of various hormonal phenotypes. Strong positive immunostaining was found for c-RET in all of the GH-secreting adenomas screened as well as in 50% of ACTH-producing adenomas. Positive immunostaining for GDNF was found in all of the GH-secreting adenomas and in 10% of the corticotropinomas. Lastly, we found strong positive immunostaining for GFRalpha1 in 90% of the somatotropinomas and 50% of the corticotropinomas as well as in 1 of 8 prolactinomas and 1 of 13 nonfuncti...Continue Reading
References
Mar 16, 1995·Brain Research. Developmental Brain Research·D L Choi-Lundberg, M C Bohn
Jul 4, 1996·Nature·J J TreanorA Rosenthal
Oct 10, 1996·Experimental Cell Research·J A CostoyaJ Devesa
Jan 1, 1997·Trends in Genetics : TIG·K Robertson, I Mason
Apr 1, 1997·Endocrine Reviews·D Ray, S Melmed
May 1, 1997·Neuron·R H BalohJ Milbrandt
Apr 3, 1998·Oncogene·C CarneiroF Domínguez
Dec 23, 1998·Endocrine Reviews·S L Asa, S Ezzat
Jul 30, 1999·Endocrine Journal·K YoshimotoM Itakura
Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·A TessitoreV Colantuoni
May 10, 2000·Endocrinology·A G UrbanoC V Alvarez
Jun 6, 2000·The British Journal of Ophthalmology·S B KayeC A Hart
Citations
Mar 14, 2009·PloS One·Montse Garcia-LavandeiraClara V Alvarez
Oct 23, 2012·Indian Journal of Endocrinology and Metabolism·Abhay GundgurthiM K Garg
Feb 2, 2013·Endocrine Reviews·Albert BeckersAuli Karhu
Jun 5, 2003·Clinical Endocrinology·Chris J McCabe, Anthony P Heaney
Mar 24, 2007·The EMBO Journal·Carmen CañibanoClara V Alvarez
Sep 1, 2017·The Journal of Endocrinology·Scott HastonJuan Pedro Martinez-Barbera
Jan 18, 2011·Endocrinology·Anne GuillouAgnès O Martin
Oct 25, 2011·Oncogene·E Diaz-RodriguezC V Alvarez
Oct 28, 2011·The Journal of Clinical Endocrinology and Metabolism·Montserrat Garcia-LavandeiraClara V Alvarez
Aug 20, 2014·Endocrinology·Esther Diaz-RodriguezClara V Alvarez
Apr 16, 2009·The Journal of Clinical Endocrinology and Metabolism·Manuela VargioluElena Bonora
Jan 10, 2014·Pituitary·Nestoras MathioudakisAlfredo Quiñones-Hinojosa
Sep 14, 2017·International Journal of Oncology·Marialuisa SpoletiniFrancesco Saverio Pastore
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Volker F H BrauerChristian A Koch
Jan 6, 2005·World Journal of Gastroenterology : WJG·Tao GuanJin-Fa Tou
Oct 1, 2021·Oncogene·Angela R Garcia-RenduelesClara V Alvarez