Glial Dysfunction in MeCP2 Deficiency Models: Implications for Rett Syndrome

International Journal of Molecular Sciences
Uri KahanovitchMichelle L Olsen

Abstract

Rett syndrome (RTT) is a rare, X-linked neurodevelopmental disorder typically affecting females, resulting in a range of symptoms including autistic features, intellectual impairment, motor deterioration, and autonomic abnormalities. RTT is primarily caused by the genetic mutation of the Mecp2 gene. Initially considered a neuronal disease, recent research shows that glial dysfunction contributes to the RTT disease phenotype. In the following manuscript, we review the evidence regarding glial dysfunction and its effects on disease etiology.

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Citations

Oct 18, 2019·International Journal of Molecular Sciences·Shilpa D KadamConstance Smith-Hicks
Oct 8, 2020·Médecine sciences : M/S·Noémie CrestoNathalie Rouach
Nov 24, 2020·Acta Neuropathologica·Tam T QuachAnne-Marie Duchemin
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Jul 10, 2021·Journal of Neuroinflammation·Giuseppe GalvaniStefania Trazzi
Feb 28, 2021·Journal of Neurochemistry·Santosh R D'Mello

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