Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity

Proceedings of the National Academy of Sciences of the United States of America
Smita YadavYuh Nung Jan

Abstract

Sensory neurons perceive environmental cues and are important of organismal survival. Peripheral sensory neurons interact intimately with glial cells. While the function of axonal ensheathment by glia is well studied, less is known about the functional significance of glial interaction with the somatodendritic compartment of neurons. Herein, we show that three distinct glia cell types differentially wrap around the axonal and somatodendritic surface of the polymodal dendritic arborization (da) neuron of the Drosophila peripheral nervous system for detection of thermal, mechanical, and light stimuli. We find that glial cell-specific loss of the chromatin modifier gene dATRX in the subperineurial glial layer leads to selective elimination of somatodendritic glial ensheathment, thus allowing us to investigate the function of such ensheathment. We find that somatodendritic glial ensheathment regulates the morphology of the dendritic arbor, as well as the activity of the sensory neuron, in response to sensory stimuli. Additionally, glial ensheathment of the neuronal soma influences dendritic regeneration after injury.

References

Jan 1, 1991·Annals of the New York Academy of Sciences·J Scholes
Jan 11, 2002·Developmental Biology·K J SeppV J Auld
Apr 23, 2003·Cell·W Daniel TraceySeymour Benzer
Feb 22, 2005·Current Opinion in Neurobiology·Gundula EdenfeldChristian Klämbt
May 26, 2005·Brain Research. Brain Research Reviews·Menachem Hanani
Oct 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Chay T KuoYuh Nung Jan
Mar 18, 2006·Neuron·Tomoko IshibashiR Douglas Fields
Mar 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Swati BanerjeeManzoor A Bhat
Nov 28, 2007·Journal of Neuroscience Research·Swati Banerjee, Manzoor A Bhat
Dec 7, 2007·Current Biology : CB·Richard Y HwangW Daniel Tracey
Jan 18, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tobias StorkChristian Klämbt
Sep 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Pierre-Luc BardetJean-Paul Vincent
Nov 21, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Claudia SeahNathalie G Bérubé
May 2, 2009·Biochemical and Biophysical Research Communications·Yoon Ki HongKyoung Sang Cho
Feb 23, 2010·Current Biology : CB·Lixian ZhongW Daniel Tracey
Apr 21, 2010·Nature Reviews. Neuroscience·Yuh-Nung Jan, Lily Yeh Jan
Sep 8, 2010·Cellular and Molecular Life Sciences : CMLS·Floriano RodriguesChristian Klämbt
Jan 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Norifumi ShiodaKohji Fukunaga
May 25, 2011·Proceedings of the National Academy of Sciences of the United States of America·Chun HanYuh-Nung Jan
Dec 24, 2011·Cold Spring Harbor Protocols·Tobias StorkMarc R Freeman
Feb 22, 2012·Nature·Sung Eun KimArdem Patapoutian
Jan 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jan E Melom, J Troy Littleton
May 18, 2013·AJNR. American Journal of Neuroradiology·T WadaN Aida
Jan 15, 2014·Cell Reports·Michelle C StoneMelissa M Rolls
Dec 3, 2014·Frontiers in Neuroscience·Stefanie LimmerChristian Klämbt
Mar 4, 2015·Proceedings of the National Academy of Sciences of the United States of America·Tsz-Leung ToXiaokun Shu
Aug 4, 2015·Cell Metabolism·Anne VolkenhoffStefanie Schirmeier
Dec 30, 2015·Nature Neuroscience·Stefanie Robel, Harald Sontheimer

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Citations

Feb 26, 2020·Developmental Neurobiology·Jonas BitternChristian Klämbt
May 17, 2019·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yasutetsu KanaokaYukako Hattori
Jan 13, 2021·Toxics·Roshni Patel, Michael Aschner
Nov 5, 2020·Wiley Interdisciplinary Reviews. Developmental Biology·Anoohya N MuppiralaSarah C Petersen
Jun 18, 2021·Frontiers in Cellular Neuroscience·Chang YinJay Z Parrish

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