PMID: 11921199Mar 29, 2002Paper

Glial expression of small heat shock proteins following an excitotoxic lesion in the immature rat brain

Glia
L AcarinB Castellano

Abstract

Heat shock proteins (HSPs) are chaperones induced under pathological conditions and involved in protein stabilization and cellular protection. In this study, we have evaluated the expression pattern of the glial cell-related HSP27, HSP32, and HSP47 following an excitotoxic lesion in the immature rat brain. Postnatal day 9 rats received an intracortical injection of N-methyl-D-aspartate and tissue was processed immunohistochemically for HSPs and double labeling using astroglial and microglial markers. HSP expression was quantified by image analysis. Excitotoxic damage caused primary cortical degeneration and secondary damage in the corresponding thalamus. In the injured cortex, reactive microglia/macrophages expressed HSP32 from 10 h until 14 days postlesion (PL), showing maximal levels at days 3-5. In parallel, most cortical reactive astrocytes showed expression of HSP47 from 10 h until 14 days PL and a population of them also displayed HSP27 labeling from 1 day PL. In addition, some cortical reactive astrocytes showed a temporary expression of HSP32 at day 1. In general, astroglial HSP expression in the cortex achieved maximal levels at days 3-5 PL. In the damaged thalamus, HSP32 was not significantly induced, but reactive ast...Continue Reading

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Citations

Jun 23, 2005·Acta Neuropathologica·Takahiro FukudaShinichiro Umemura
Dec 16, 2004·Proteome Science·Jae-Kyung MyungGert Lubec
Sep 1, 2006·Developmental Neuroscience·Hülya BayirValerian E Kagan
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