PMID: 7020324Jan 1, 1981Paper

Glial fibrillary acidic protein in stromal cells of some capillary hemangioblastomas: significance and possible implications of an immunoperoxidase study

Acta Neuropathologica
J H Deck, L J Rubinstein

Abstract

Thirty-nine hemangioblastomas from 26 patients were studied by the immunoperoxidase method for GFA protein. Reactive gliosis in the form of trapped GFA protein-positive astrocytes or astrocytic cell processes penetrated the margins of all the neuraxial tumors and none of those occurring on nerve roots or in the tumor explants maintained in an organ culture system. Gliosis was especially prominent in tumors recurring after surgical excision or in patients with a long history of tumor. In six tumors, representing both the reticular and the cellular variants of hemangioblastoma, GFA protein-positive stromal cells were also found, chiefly in the periphery of the neoplasma: all these tumors were surrounded by dense reactive gliosis. Four hypotheses accounting for the presence of GFA protein-positive stromal cells are considered: (1) The tumors are astrocytomas. (2) The GFA protein-positive cells are not neoplastic but lipidized or altered reactive astrocytes. (3) The tumors are mixed and partly composed of neoplastic astrocytes. (4) The stromal cells are capable of taking up extracellular GFA protein derived from the adjacent reactive astrocytes. The last of these hypotheses is the most consistent with the collective evidence derive...Continue Reading

References

Mar 1, 1979·Journal of the National Cancer Institute·C M JacqueN Baumann
Jul 1, 1977·Journal of Neuropathology and Experimental Neurology·P E DuffyM M Rapport
Oct 1, 1978·Cancer·A P ChaudhryG A Cohn
Aug 1, 1978·The Journal of Cell Biology·J E GoldmanW T Norton
Jul 19, 1976·Biochimica Et Biophysica Acta·G H De VriesM G Hadfield
Nov 1, 1976·Cancer·F A JakobiecF B Johnson
Feb 1, 1975·Journal of Neurology, Neurosurgery, and Psychiatry·R Jeffreys
Feb 11, 1972·Brain Research·C T UyedaA Bignami
Jun 1, 1973·Cancer·J KawamuraY Kamijyo

❮ Previous
Next ❯

Citations

Jan 1, 1987·Acta Neuropathologica·H KamitaniI Kanazawa
Jan 1, 1983·Histopathology·D I GrahamI Brown
Jun 2, 2014·Brain Tumor Pathology·Ayako TomonoTomoo Itoh
Jan 1, 1988·Acta Neuropathologica·J W GrantC Hedinger
Jan 1, 1995·Neurosurgery·J A BrodkeyT F O'Brien
Jan 1, 1988·Histopathology·J W IronsideW R Timperley
Jan 1, 1987·Acta Neuropathologica·J A Feldenzer, P E McKeever
Mar 1, 2012·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Qing-xu YangZhi Li
Jan 1, 1991·Acta Neuropathologica·E PerentesS R Qureshi
Jan 1, 1986·Acta Neuropathologica·D SchifferG Giaccone
Nov 5, 1997·Annals of the New York Academy of Sciences·J J Kepes, F Slowik
Apr 23, 2005·Neurosurgical Focus·Melike MutMark Shaffrey
Sep 20, 2007·International Journal of Experimental Pathology·Mahmoud R Hussein
Oct 3, 1999·Journal of Neurosurgery·F RoncaroliW E Krauss
Nov 12, 2005·Neuropathology and Applied Neurobiology·M HasselblattW Paulus
Apr 26, 2002·Neuropathology and Applied Neurobiology·S A Adams, D A Hilton

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.