Glial Fibrillary Acidic Protein in the Diagnosis and Prognosis of Malignant Glial Tumors.

Bulletin of Experimental Biology and Medicine
N V LyubimovaN E Kushlinskii

Abstract

Serum levels of glial fibrillar acidic protein (GFAP) were analyzed in 317 patients with primary and metastatic tumors of the brain, 78 patients with neurological diseases, and 66 normal subjects. A significant increase in the basal level of GFAP was typical of patients with glioblastomas in comparison with other groups (patients with astrocytomas, cerebral metastases, benign tumors, non-tumor diseases, and healthy subjects). An association of GFAP levels with unfavorable prognosis of overall survival in patients with glioblastoma was revealed. The data attest to high specificity and sensitivity of GFAP as a biochemical marker of glioblastoma.

References

Jan 1, 1982·Scandinavian Journal of Immunology. Supplement·L F Eng
Nov 8, 2007·Acta Neurologica Scandinavica·T BrommelandV Isaksen
Nov 14, 2007·Brain : a Journal of Neurology·C S JungM Sitzer
Jan 12, 2012·Bulletin of Experimental Biology and Medicine·N V LyubimovaN E Kushlinskii
Apr 18, 2013·Biochemistry. Biokhimii︠a︡·Ph A KoshkinV P Chekhonin
May 26, 2018·Journal of Neuro-oncology·Peter BaumgartenChristian Senft

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Citations

Jun 22, 2021·Frontiers in Oncology·Hamza AliMyron G Best
Jul 2, 2021·International Journal of Cancer. Journal International Du Cancer·Amélie DarlixSylvain Lehmann

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