Glial fibrillary acidic protein in the retina of the developing albino rat: an immunoperoxidase study of paraffin-embedded tissue

The Journal of Comparative Neurology
R G Dixon, L F Eng

Abstract

The peroxidase-anti-peroxidase method was used on paraffin-embedded material to demonstrate the distribution of glial fibrillary acidic (GFA) protein, an astrocyte-specific protein, in the developing retina of the albino rat. At birth activity was scant and was confined to scattered, poorly differentiated cells in the inner retinal layers near the optic disc. At 3 days primitive astrocytes which displayed GFA protein activity were confined to the stratum opticum near the optic disc. With increasing age these cells were found at greater distances from the optic disc and began to assume the appearance of typical fibrous astrocytes. By 30 days the perikarya of these cells were confined almost exclusively to the region between the nerve fiber layer and the inner limiting membrane. The processes of these cells terminated either in suckerlike end-feet upon blood vessels or, to a lesser extent, ended in relation to axon fascicles of the nerve fiber layer. A second population of GFA protein-active cells existed as perivascular glia which were found upon vessels in the inner portion of the stratum opticum in young animals. In the mature retina perivascular glia were found on vessels throughout the stratum opticum and in the inner portio...Continue Reading

References

Jan 1, 1978·Advances in Experimental Medicine and Biology·L F EngM Kies
Jul 1, 1978·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L F Eng, L J Rubinstein
Jan 1, 1975·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·H Inomata
Aug 1, 1969·Archives of Ophthalmology·E Yamada
Jun 1, 1972·Journal of Ultrastructure Research·K E Rasmussen
Feb 11, 1972·Brain Research·C T UyedaA Bignami
Jul 1, 1973·Journal of Ultrastructure Research·K E Rasmussen
Jan 1, 1971·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·B Daicker
Jan 1, 1965·Acta Ophthalmologica·E Korhonen, L K Korhonen
Apr 1, 1968·Archives of Ophthalmology·A J Kroll
Dec 1, 1970·The Journal of Comparative Neurology·L Sosula, P H Glow
Jan 1, 1965·Progress in Brain Research·A Lasansky
Jun 1, 1966·The Journal of Comparative Neurology·C P Wendell-SmithF Baldwin
Jun 1, 1966·The British Journal of Ophthalmology·M Shakib, N Ashton
Dec 1, 1956·The Annals of Otology, Rhinology, and Laryngology·L LISS
Apr 1, 1957·A.M.A. Archives of Ophthalmology·J R WOLTER
Dec 1, 1957·American Journal of Ophthalmology·J R WOLTER
Oct 1, 1958·A.M.A. Archives of Ophthalmology·W K NOELL
Feb 1, 1959·American Journal of Ophthalmology·J R WOLTER, W W WILSON
Jan 1, 1959·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T KUWABARAJ H KINOSHITA
Dec 1, 1960·Archives of Ophthalmology·T KUWABARA, D G COGAN
Jul 1, 1960·The Journal of General Physiology·G M VILLEGAS
Nov 1, 1959·American Journal of Ophthalmology·J R WOLTER
Oct 1, 1961·Archives of Ophthalmology·J R WOLTER
Nov 1, 1963·Archives of Ophthalmology·S LESSELL, T KUWABARA
Aug 1, 1963·Journal of Ultrastructure Research·M J HOGAN, L FEENEY
Aug 1, 1963·Journal of Ultrastructure Research·M J HOGAN, L FEENEY
Jun 1, 1964·The Journal of Comparative Neurology·P G VAIDYA
Oct 1, 1963·The British Journal of Ophthalmology·C A ERSKINE
Jun 1, 1955·A.M.A. Archives of Ophthalmology·J R WOLTER
Sep 1, 1961·Experimental Eye Research·A T KISSEN, J M BLOODWORTH
Jan 1, 1961·Transactions of the American Ophthalmological Society·T KUWABARA, D COGAN
Nov 1, 1961·Archives of Ophthalmology·T KUWABARA, D G COGAN
May 1, 1952·American Journal of Ophthalmology·G G SMITH, C D BAIRD
Jan 1, 1950·Archives of Ophthalmology·W TURNBULL
Jun 1, 1961·The British Journal of Ophthalmology·C Pedler

❮ Previous
Next ❯

Citations

Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·G TerenghiA Garner
Dec 1, 1991·Cellular and Molecular Neurobiology·P V SarthyJ Huang
Oct 1, 1988·Journal of Neurocytology·V P GaurP V Sarthy
Jan 1, 1984·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·R H Rhodes
Dec 3, 1990·Brain Research·M del CerroC del Cerro
Aug 1, 1984·Brain Research·S K PixleyJ de Vellis
Nov 1, 1988·Brain Research. Developmental Brain Research·T L Ling, J Stone
Jan 1, 1988·Visual Neuroscience·Z DreherJ Stone
Mar 1, 1993·Visual Neuroscience·A FeigenspanH Wässle
Apr 28, 1988·Nature·T Watanabe, M C Raff
Jan 1, 1988·Eye·F J SavageI Grierson
Apr 1, 1996·The Kobe Journal of Medical Sciences·M M KarimH Ito
Jan 1, 1990·Neurochemistry International·S E JonesM J Neal
Jun 1, 1986·Journal of Neuroimmunology·M N CourelC Chauzy
Mar 22, 1991·The Journal of Comparative Neurology·S L Semple-Rowland
Aug 1, 1990·Journal of Comparative Pathology·M DavidsonJ Kornegay
Jan 1, 1987·Experimental Eye Research·P A EricksonD D Kaska
Oct 21, 1998·Experimental Eye Research·M H Chaitin, A M Brun-Zinkernagel
Jul 1, 1996·Vision Research·J M RamírezJ García-Sánchez
Jul 22, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mauro LeonelliLuiz R G Britto

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