Glial fibrillary acidic protein levels are associated with global histone H4 acetylation after spinal cord injury in rats

Neural Regeneration Research
Mayara Ferraz de MenezesRégis Gemerasca Mestriner

Abstract

Emerging evidence has suggested global histone H4 acetylation status plays an important role in neural plasticity. For instance, the imbalance of this epigenetic marker has been hypothesized as a key factor for the development and progression of several neurological diseases. Likewise, astrocytic reactivity - a well-known process that markedly influences the tissue remodeling after a central nervous system injury - is crucial for tissue remodeling after spinal cord injury (SCI). However, the linkage between the above-mentioned mechanisms after SCI remains poorly understood. We sought to investigate the relation between both glial fibrillary acidic protein (GFAP) and S100 calcium-binding protein B (S100B) (astrocytic reactivity classical markers) and global histone H4 acetylation levels. Sixty-one male Wistar rats (aged ~3 months) were divided into the following groups: sham; 6 hours post-SCI; 24 hours post-SCI; 48 hours post-SCI; 72 hours post-SCI; and 7 days post-SCI. The results suggested that GFAP, but not S100B was associated with global histone H4 acetylation levels. Moreover, global histone H4 acetylation levels exhibited a complex pattern after SCI, encompassing at least three clearly defined phases (first phase: no chan...Continue Reading

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Citations

Feb 20, 2021·ASN Neuro·Michael Brenner, Albee Messing

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Methods Mentioned

BETA
histone acetylation
acetylation
dissection
ELISA
histone-acetylation

Software Mentioned

ImageJ
SPSS

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