Glial hyaluronate-binding protein in dysmyelinating mice mutants: jimpy, quaking and shiverer.

Acta Neuropathologica
A Bignami, G Perides

Abstract

Cryostat sections of cerebral hemispheres, cerebellum and spinal cord from dysmyelinating mice mutants (quaking, jimpy and shiverer) and littermate controls were stained by indirect immunofluorescence with polyclonal antibodies to the glial hyaluronate-binding protein (GHAP), a brain-specific extracellular matrix glycoprotein produced by astrocytes. In normal mice, the distribution of GHAP was similar to that previously reported in human, calf, pig and dog. The antigen was mainly localized in white matter, the granular layer of the cerebellum being the main exception. No differences were observed between mutants and littermate controls, except that with both GHAP and glial fibrillary acidic protein antibodies the glial framework was denser in the mutants, probably due to the reduction in myelin. The findings suggest that GHAP expression by astrocytes is not induced by myelination and that white matter astrocytes constitute a distinct glial population.

References

May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A Bignami, D Dahl
Oct 1, 1986·Journal of Neurocytology·A Bignami, D Dahl
Jan 1, 1987·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D DahlC J Crosby
Mar 1, 1989·Journal of Neuropathology and Experimental Neurology·A BignamiD Dahl
Jan 1, 1989·Brain Research Bulletin·A BignamiD Dahl

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Citations

Jan 1, 1990·Scandinavian Journal of Rheumatology. Supplement·P Ivanyi

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