PMID: 8553890Oct 1, 1995

Glial-like cells of the rat pituitary intermediate lobe change morphology and shift from vimentin to GFAP expression during development

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
K A GaryB M Chronwall

Abstract

This study demonstrated morphological changes in glial-like cells of the rat pituitary intermediate lobe during early postnatal development, and a subsequent shift in protein expression from vimentin to GFAP. Vimentin immunoreactivity was detected in the lobe at embryo day 14 and was localized in radially-oriented, bipolar cells whose processes spanned the thickness of the intermediate lobe. At electron microscopical resolution, processes contained intermediate filaments, cell nuclei were indented while secretory vesicles characteristic of the endocrine cells were not found. Vimentin immunoreactive intensity began to decrease at postnatal day 5. By postnatal day 7, vimentin-positive, stellate cells were observed, with few radial processes found by day 10. The intensity of vimentin immunoreactivity decreased through day 25. Within the lobe parenchyma, vimentin was localized in glial-like cells since double-label immunohistochemistry revealed no colocalization of beta-endorphin and vimentin, or fibronectin and vimentin. Dopamine-containing axons were in close apposition to vimentin-positive processes. GFAP immunoreactivity first appeared on postnatal day 20 and, by day 25, stellate cell bodies with three to six extended processes...Continue Reading

References

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Citations

Apr 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·B M ChronwallK A Gary
Jun 2, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Maya Gadhvi PurisaiB M Chronwall
Sep 9, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·B M ChronwallJ P Schwartz
Jun 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S A Sands, B M Chronwall
Aug 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D M BeattyB M Chronwall

Related Concepts

Axon
Beta-Endorphin
Embryonic and Fetal Development
Fibronectins
Immunofluorescence Assay
Glial Fibrillary Acidic Protein
Neuroglia
Pituitary Stalk
Tyrosine 3-Monooxygenase
Vimentin

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Related Papers

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
S A SandsB M Chronwall
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