Glial precursor cell transplantation therapy for neurotrauma and multiple sclerosis

Progress in Histochemistry and Cytochemistry
Iris KulbatskiCharles H Tator

Abstract

Traumatic injury to the brain or spinal cord and multiple sclerosis (MS) share a common pathophysiology with regard to axonal demyelination. Despite advances in central nervous system (CNS) repair in experimental animal models, adequate functional recovery has yet to be achieved in patients in response to any of the current strategies. Functional recovery is dependent, in large part, upon remyelination of spared or regenerating axons. The mammalian CNS maintains an endogenous reservoir of glial precursor cells (GPCs), capable of generating new oligodendrocytes and astrocytes. These GPCs are upregulated following traumatic or demyelinating lesions, followed by their differentiation into oligodendrocytes. However, this innate response does not adequately promote remyelination. As a result, researchers have been focusing their efforts on harvesting, culturing, characterizing, and transplanting GPCs into injured regions of the adult mammalian CNS in a variety of animal models of CNS trauma or demyelinating disease. The technical and logistic considerations for transplanting GPCs are extensive and crucial for optimizing and maintaining cell survival before and after transplantation, promoting myelination, and tracking the fate of tr...Continue Reading

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Citations

Mar 16, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Akshata AlmadDana M McTigue
Dec 17, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jian-Guo HuHe-Zuo Lü
Feb 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qilin CaoScott R Whittemore
Jan 29, 2021·Frontiers in Cellular Neuroscience·Anne Huntemer-SilveiraAnn M Parr

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