Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis

Journal of Neuropathology and Experimental Neurology
Johanna M H AnneserPamela J Shaw

Abstract

Accumulating evidence indicates that alterations in glial activation and disturbances in glial glutamate metabolism may contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS). Metabotropic glutamate receptors (mGluRs) are involved in glutamate homeostasis as well as in glial proliferation. Using in situ hybridization and immunohistochemistry we found a strong upregulation of group I and group II mGluR mRNA and protein in ALS spinal cord as compared to controls (mGluR5 > mGluR1 > mGluR2/3). In vitro, the mGluR group I agonist 3,5-dihydroxyphenylglycine induced proliferation in chick spinal cord astroglial cultures. Moreover, addition of cerebrospinal fluid (CSF) from ALS patients resulted in significantly higher proliferation rates than control CSF. In both cases, the effect could be blocked by addition of the mGluR group I antagonist 1-aminoindan-1,5-dicarboxylic acid. Taken together, our data suggest that stimulation of glial mGluRs through mediators present in the CSF may contribute to glial proliferation and astrogliosis in ALS.

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Citations

Jul 6, 2016·Human Molecular Genetics·Kim A StaatsLudo Van Den Bosch
Aug 8, 2018·The International Journal of Neuroscience·Jing Wang
Nov 30, 2018·Frontiers in Molecular Neuroscience·Simona Federica SpampinatoFilippo Caraci
Mar 22, 2007·Muscle & Nerve·Clemens NeuschChristiane Schneider-Gold
Mar 27, 2015·Journal of Cellular and Molecular Medicine·Vega García-EscuderoFilip Lim
Nov 13, 2015·Expert Opinion on Biological Therapy·Letizia MazziniAlessandro Vercelli
Oct 29, 2009·Journal of Neurochemistry·Shan ChengJunqi He
Apr 2, 2015·Archives of Toxicology·Olga Gorelenkova Miller, John J Mieyal
Oct 18, 2005·Muscle & Nerve·Thais Federici, Nicholas M Boulis
Jan 9, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Rajapillai L I Pillai, Dnyanesh N Tipre
Jul 7, 2005·Journal of Neurochemistry·Céline VermeirenEmmanuel Hermans
Apr 6, 2021·Frontiers in Molecular Neuroscience·Koy Chong Ng Kee KwongArpan R Mehta
May 21, 2021·Eye and Brain·Vladislav O SoldatovAlexey V Deykin

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