Glial reactions and degeneration of myelinated processes in spinal cord gray matter in chronic experimental autoimmune encephalomyelitis.

Neuroscience
J WuL A Havton

Abstract

Multiple sclerosis and experimental autoimmune encephalomyelitis (EAE) result in inflammatory white matter lesions in the CNS. However, information is sparse with regard to the effects of autoimmune demyelinating disease on gray matter regions. Therefore, we studied the late effects of chronic EAE in C57BL/6 mice on the spinal cord gray matter using immunohistochemistry. Here, EAE induced marked astrocytic, microglial, and macrophage activation in the ventral horn gray matter, without any motoneuron loss. Activated caspase-3 was also increased in the ventral horn gray matter. Furthermore, activated poly (ADP-ribose) polymerase (PARP), another apoptotic marker, co-localized with myelin basic protein (MBP) of oligodendrocyte processes, but not with the oligodendroglial cell body marker, adenomatous polyposis coli gene clone CC1 (APC-CC1), or with neurofilament marker (RT-97) or synaptophysin of axonal arbors. However, there was no associated increase in the number of terminal deoxynucleotidyl transferase (TdT) mediated-dUTP nick end labeling positive nuclei in the spinal cord gray matter of EAE mice. In addition, co-localization of MBP and the low-affinity neurotrophin receptor, p75, was demonstrated, further supporting the notio...Continue Reading

References

Aug 1, 1990·Journal of Electron Microscopy Technique·H J Ralston
Jul 1, 1991·Journal of the Neurological Sciences·M P PenderJ F Kerr
Jul 1, 1995·Trends in Neurosciences·M V Chao, B L Hempstead
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·M P RamprasadD Steinberg
Jan 20, 1997·The Journal of Comparative Neurology·P G PopovichB T Stokes
Oct 23, 1997·The Journal of Experimental Medicine·W E SuenN H Ruddle
Jan 29, 1998·The New England Journal of Medicine·B D TrappL Bö
Nov 17, 1998·Seminars in Neurology·C F LucchinettiH Lassmann
Jul 30, 1999·Journal of Neuroimmunology·B D TrappA Chang
Sep 14, 1999·Brain Research Bulletin·J W Fawcett, R A Asher
Nov 15, 2001·Annals of Neurology·J W PrineasB P Morgan
Feb 8, 2002·Molecular Neurobiology·A G Yakovlev, A I Faden
Feb 15, 2002·Brain : a Journal of Neurology·D T ChardD H Miller
May 4, 2002·Science·Martin C RaffJohn T Finn
Aug 3, 2005·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·David P StirlingWolfram Tetzlaff
Sep 9, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rina AharoniRaya Eilam
Dec 2, 2005·Journal of Neuropathology and Experimental Neurology·Marco VercellinoPaola Cavalla
Jun 30, 2006·NeuroImage·Allan MacKenzie-GrahamArthur W Toga

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Citations

Feb 2, 2013·Molecular Aspects of Medicine·Nicola J Curtin, Csaba Szabo
Aug 19, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fuzheng GuoDavid Pleasure
Apr 8, 2010·Free Radical Research·Irene PaternitiSalvatore Cuzzocrea
Mar 19, 2014·International Journal of Experimental Pathology·Yong LiuQianning Li
Sep 18, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jang-Mi ParkMun-Yong Lee
Feb 14, 2013·Current Protocols in Stem Cell Biology·Maria Inês MorteInês M Araújo

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