Glial S100B is elevated in serum across the spectrum of West Nile virus infection

Muscle & Nerve
A A LeisA Petzold

Abstract

We previously reported that protein biomarkers of neuronal death and glial pathology were elevated in the cerebrospinal fluid of patients with West Nile virus (WNV) infection, including WNV fever. Therefore, we hypothesized that the glial biomarker S100B would also be elevated in serum across the spectrum of WNV disease. Serum levels of S100B were measured by enzyme-linked immunoassay (ELISA) in 90 WNV patients (35 with neuroinvasive disease and 55 with WNV fever) and compared with 34 healthy controls. Serum S100B was significantly higher in patients (median 0.17 ng/ml) than in controls (0.09 ng/ml, P < 0.0001). Serum S100B was elevated in 16 cases (46%) with neuroinvasive disease and in 19 cases (35%) with WNV fever. The increase in serum S100B reaffirms pathological changes across the spectrum of WNV disease. The elevated S100B in over one third of WNV fever cases implies that neuroinvasion occurs in a much greater proportion of patients than anticipated by clinical and epidemiological data.

References

Jun 4, 1999·Stroke; a Journal of Cerebral Circulation·M T WunderlichM Herrmann
Jun 16, 2001·The New England Journal of Medicine·D NashUNKNOWN 1999 West Nile Outbreak Response Working Group
Aug 6, 2002·Annals of Internal Medicine·Lyle R Petersen, Anthony A Marfin
Oct 2, 2002·MMWR. Morbidity and Mortality Weekly Report·UNKNOWN Centers for Disease Control and Prevention (CDC)
Oct 25, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·W J TownendD W Yates
Nov 2, 2002·Journal of the American Geriatrics Society·Yitshal N BernerMichal Y Chowers
Dec 31, 2002·The Lancet Infectious Diseases·A Arturo LeisSally A Slavinski
Feb 7, 2003·The New England Journal of Medicine·Peter T Rowley
Feb 7, 2003·The New England Journal of Medicine·Todd W KelleyCarlos M Isada
May 23, 2003·American Journal of Clinical Pathology·Todd W KelleySteven M Gordon
Jul 24, 2003·JAMA : the Journal of the American Medical Association·James J SejvarLyle R Petersen
Aug 2, 2003·Emerging Infectious Diseases·James J SejvarLyle R Petersen
Aug 12, 2003·Brain Research Bulletin·A PetzoldE J Thompson
Aug 21, 2003·Muscle & Nerve·A Arturo LeisJonathan Fratkin
Mar 6, 2004·Scandinavian Journal of Infectious Diseases·Johan UndénBertil Romner
Jun 24, 2004·The Journal of Trauma·Olli SavolaMatti Hillbom
Sep 9, 2004·Annals of Internal Medicine·John T WatsonSusan I Gerber
Oct 22, 2004·Emerging Infectious Diseases·Anne Labowitz KleeDenis Nash
Dec 22, 2004·Current Treatment Options in Neurology·A Arturo Leis, Dobrivoje S Stokic
Jan 18, 2006·Annual Review of Medicine·Edward B Hayes, Duane J Gubler
Aug 25, 2006·Journal of Neurotrauma·Andrea Kleindienst, M Ross Bullock
Sep 20, 2006·Annals of Neurology·Larry E DavisKenneth L Tyler
May 25, 2007·Neurocritical Care·Stephen M BloomfieldJonathan Brisman
Oct 14, 2009·Journal of Neuropsychology·James J SejvarGrant L Campbel
Nov 18, 2009·Journal of Neuropathology and Experimental Neurology·Kymberly A Gyure
Sep 17, 2010·PloS One·Nancy PhamDamir Janigro

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Citations

Sep 19, 2015·Journal of the Neurological Sciences·R B KuwarP J S Vig
Aug 28, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P PerrinS Caillard
Nov 26, 2020·Pathogens and Disease·Thekra KhushafaZhu Haixia

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