Glibenclamide Prevents Water Diffusion Abnormality in the Brain After Cardiac Arrest in Rats

Neurocritical Care
Kaibin HuangYongming Wu

Abstract

Glibenclamide (GBC) improves neurological outcome after cardiac arrest (CA) in rats. In this study, we sought to elucidate the mechanism responsible for the neuroprotective effects of GBC by using a high-field MRI system. Male Sprague-Dawley rats were subjected to 10-min asphyxial CA followed by cardiopulmonary resuscitation (CPR). Diffusion-weighted imaging (DWI) as well as conventional T2-weighted imaging was conducted prior to CA and at 24, 48, and 72 h after resuscitation. Afterward, histological examination was performed. Twelve rats were randomized to receive GBC (n = 6) or vehicle (n = 6) at 15 min after return of spontaneous circulation, while four rats were set as sham control. Rats that underwent CA/CPR and received vehicle exhibited distinct neurological deficit, which was alleviated by GBC treatment. Marked water diffusion abnormality as demonstrated by hyperintense DWI in vulnerable regions of the brain was detected after CA/CPR, with the most prominent hyperintense DWI observed in the hippocampal CA1 region at 72 h. Consistently, histological examination revealed neuronal swelling, dendritic injury, and activation of astrocytes and microglia in the hippocampal CA1 region in vehicle-treated rats. Correlation analys...Continue Reading

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Citations

Oct 19, 2019·Expert Opinion on Investigational Drugs·Melissa PergakisJ Marc Simard
Jan 16, 2020·International Journal of Molecular Sciences·Ruchira M JhaJ Marc Simard
Jan 21, 2021·Expert Opinion on Pharmacotherapy·Melissa PergakisJ Marc Simard
Jul 17, 2021·Neurocritical Care·Alaa OustaWillard W Sharp
Jul 15, 2021·Critical Care Medicine·Heidi J DaltonRobert H Bartlett
Oct 3, 2021·Neurocritical Care·Brittany Bolduc LachanceXiaofeng Jia

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