Glibenclamide Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

Journal of Neurotrauma
Ruchira M JhaPatrick M Kochanek

Abstract

Glibenclamide (GLY) is the sixth drug tested by the Operation Brain Trauma Therapy (OBTT) consortium based on substantial pre-clinical evidence of benefit in traumatic brain injury (TBI). Adult Sprague-Dawley rats underwent fluid percussion injury (FPI; n = 45), controlled cortical impact (CCI; n = 30), or penetrating ballistic-like brain injury (PBBI; n = 36). Efficacy of GLY treatment (10-μg/kg intraperitoneal loading dose at 10 min post-injury, followed by a continuous 7-day subcutaneous infusion [0.2 μg/h]) on motor, cognitive, neuropathological, and biomarker outcomes was assessed across models. GLY improved motor outcome versus vehicle in FPI (cylinder task, p < 0.05) and CCI (beam balance, p < 0.05; beam walk, p < 0.05). In FPI, GLY did not benefit any other outcome, whereas in CCI, it reduced 21-day lesion volume versus vehicle (p < 0.05). On Morris water maze testing in CCI, GLY worsened performance on hidden platform latency testing versus sham (p < 0.05), but not versus TBI vehicle. In PBBI, GLY did not improve any outcome. Blood levels of glial fibrillary acidic protein and ubiquitin carboxyl terminal hydrolase-1 at 24 h did not show significant treatment-induced changes. In summary, GLY showed the greatest benefit ...Continue Reading

References

Oct 1, 1991·Journal of Neuroscience Methods·C E DixonR L Hayes
Mar 11, 1991·The American Journal of Physiology·A BobikS Grinpukel
Jul 1, 1987·Journal of Neurosurgery·C E DixonR L Hayes
May 1, 1986·Stroke; a Journal of Cerebral Circulation·J B BedersonH Bartkowski
Jan 17, 2002·Journal of Neurosurgery·Matthias OertelNeil A Martin
Dec 12, 2002·Diabetes·Peter ProksFrances Ashcroft
May 18, 2006·Journal of Neurosurgery·Anthony MarmarouM Ross Bullock
Feb 17, 2007·Lancet Neurology·J Marc SimardVolodymyr Gerzanich
Nov 6, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Suresh Babu NaraharisettiJashvant D Unadkat
May 22, 2008·Journal of Neurotrauma·Raj K NarayanUNKNOWN Traumatic Intracerebral Hemorrhage Study Group
Nov 22, 2008·Stroke; a Journal of Cerebral Circulation·J Marc SimardVolodymyr Gerzanich
Jan 24, 2009·Neurocritical Care·Kristine H O'PhelanCherylee W J Chang
Jul 17, 2009·Journal of Neurotrauma·J Marc SimardVolodymyr Gerzanich
Jan 23, 2010·Stroke; a Journal of Cerebral Circulation·J Marc SimardVolodymyr Gerzanich
Nov 26, 2010·Journal of Neuropathology and Experimental Neurology·Ashish D PatelJ Marc Simard
Oct 13, 2011·Journal of Neurotrauma·David KurlandJ Marc Simard
Dec 27, 2011·Experimental Neurology·J Marc SimardVolodymyr Gerzanich
Jun 19, 2012·Translational Stroke Research·J Marc SimardVolodymyr Gerzanich
Jun 21, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J Marc SimardVolodymyr Gerzanich
Sep 22, 2012·Annals of the New York Academy of Sciences·J Marc SimardVolodymyr Gerzanich
Dec 21, 2012·The Journal of Biological Chemistry·Seung Kyoon WooJ Marc Simard
Feb 16, 2013·Journal of Neurotrauma·J Susie ZoltewiczFrank C Tortella
Apr 5, 2013·Neurology·Stefania MondelloAndreas Jeromin
Oct 18, 2013·Neurocritical Care·J Marc SimardVolodymyr Gerzanich
Mar 29, 2014·Neurocritical Care·Kevin N ShethPitchaiah Mandava
Jun 18, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Jens KuhleSteven Casha
Jul 15, 2015·Journal of Neuropathology and Experimental Neurology·Rupal I MehtaJ Marc Simard
Sep 24, 2015·Journal of Neurotrauma·Tamara Martínez-ValverdeJuan Sahuquillo
Nov 7, 2015·Journal of Neurotrauma·Andrea MountneyDeborah Ann Shear
Dec 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jesse A StokumJ Marc Simard
Dec 17, 2015·Journal of Neurotrauma·Helen M BramlettPatrick M Kochanek
Dec 17, 2015·Journal of Neurotrauma·Deborah A ShearFrank C Tortella

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Citations

Apr 13, 2021·Journal of Neurotrauma·Nicole D OsierC Edward Dixon

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Clinical Trials Mentioned

NCT02864953
NCT03954041

Software Mentioned

OBTT
SAS
R

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