PMID: 3743926Jul 1, 1986Paper

Glicentin 1-61 probably represents a major fraction of glucagon-related peptides in plasma of anaesthetized uraemic pigs

Diabetologia
F G Baldissera, J J Holst

Abstract

Uraemia was induced in pigs by ligation of the renal vascular pedicle, and uraemic plasma was analysed for glucagon and glucagon-related peptides. A preponderance of large molecular weight (Mr) components comprising glicentin and moieties of slightly lower Mr was found, accounting for 73 +/- 3% (mean +/- SEM, n = 12) of the total plasma glucagon-like immunoreactivity. Comparisons with glicentin 1-61, produced by controlled, stepwise, consecutive digestion of purified natural glicentin with carboxypeptidases (carboxypeptidase A followed by carboxypeptidase B, and again by carboxypeptidase A and B), gel filtration, ion exchange chromatography, reverse phase HPLC and radioimmunoassays for the glucagon sequences 6-15 and 19-29 and for the glicentin sequence 12-30 all indicate that glicentin 1-61 constitutes approximately 57% of the large Mr glucagon-related peptides found in uraemia in pigs.

References

Nov 1, 1976·The Journal of Clinical Investigation·D S EmmanouelA H Huen
Apr 1, 1975·Annals of Internal Medicine·G L BilbreyJ P Knochel
Jan 1, 1985·FEBS Letters·S P SheikhJ J Holst
Aug 1, 1974·Metabolism: Clinical and Experimental·P J LefebvreH Nizet
Jun 1, 1973·Scandinavian Journal of Clinical and Laboratory Investigation·J F Rehfeld, F Stadil
Apr 1, 1983·Regulatory Peptides·F G BaldisseraJ J Holst
Nov 1, 1983·Diabetologia·J J HolstF Stadil
May 1, 1980·The Biochemical Journal·J J Holst
May 1, 1981·Regulatory Peptides·L Thim, A J Moody

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Citations

Aug 17, 2011·Diabetes, Obesity & Metabolism·J J HolstF K Knop
Jan 28, 2015·Journal of Diabetes and Its Complications·Rune Ehrenreich KuhreJens Juul Holst
Dec 22, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Morten B JørgensenBo Feldt-Rasmussen
Oct 12, 2007·Physiological Reviews·Jens Juul Holst

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