Glioblastoma-activated pericytes support tumor growth via immunosuppression

Cancer Medicine
Isadora F G SenaAlexander Birbrair

Abstract

Glioblastoma multiforme is the most common and aggressive primary brain tumor, with an extremely poor prognosis. The lack of detailed knowledge about the cellular and molecular mechanisms involved in glioblastoma development restricts the design of efficient therapies. A recent study using state-of-art technologies explores the role of pericytes in the glioblastoma microenvironment. Glioblastoma-activated pericytes develop an immunosuppressive phenotype, reducing T-cell activation through the induction of an anti-inflammatory response. Strikingly, pericytes support glioblastoma growth in vitro and in vivo. Here, we describe succinctly the results and implications of the findings reported in pericytes' and glioblastomas' biology. The emerging knowledge from this study will be essential for the treatment of brain tumors.

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Citations

Mar 25, 2018·Cellular & Molecular Immunology·Julia P AndreottiAlexander Birbrair
May 16, 2018·Angiogenesis·Daniel A P GuerraAlexander Birbrair
Aug 3, 2018·Annals of Hematology·Erika Costa de AlvarengaAlexander Birbrair
Oct 28, 2018·Neuroscience Bulletin·Gabryella S P SantosAlexander Birbrair
Jul 7, 2019·Journal of Cellular and Molecular Medicine·Caroline LeonelAlexander Birbrair
Oct 4, 2020·Cellular and Molecular Neurobiology·Sara Santos BernardesAlexander Birbrair
Sep 12, 2018·Cancer Metastasis Reviews·Patrick O AzevedoAlexander Birbrair
Jun 6, 2020·Frontiers in Immunology·Alireza Labani-MotlaghAngelica Loskog
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Nov 16, 2018·Frontiers in Pharmacology·Clara FernandesMayur C Yergeri
Oct 29, 2020·Stem Cells Translational Medicine·Caroline C PicoliAlexander Birbrair
May 24, 2018·Cancer Research·Ana E PaivaAlexander Birbrair
Jan 24, 2021·Expert Opinion on Therapeutic Targets·Hans-Georg WirschingMichael Weller
Nov 3, 2020·Current Tissue Microenvironment Reports·LaDeidra Monet Roberts, Jennifer Munson
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Oct 12, 2020·Signal Transduction and Targeted Therapy·Mrinal K GhoshMalini Basu
Oct 16, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Silvia ToricesMichal Toborek
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Nov 5, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Gabryella S P SantosAlexander Birbrair

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Methods Mentioned

BETA
confocal microscopy

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