Glioblastoma cancer stem cell biology: Potential theranostic targets

Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
Farzaneh SharifzadAmir Ali Hamidieh

Abstract

Glioblastoma multiforme (GBM) is among the most incurable cancers. GBMs survival rate has not markedly improved, despite new radical surgery protocols, the introduction of new anticancer drugs, new treatment protocols, and advances in radiation techniques. The low efficacy of therapy, and short interval between remission and recurrence, could be attributed to the resistance of a small fraction of tumorigenic cells to treatment. The existence and importance of cancer stem cells (CSCs) is perceived by some as controversial. Experimental evidences suggest that the presence of therapy-resistant glioblastoma stem cells (GSCs) could explain tumor recurrence and metastasis. Some scientists, including most of the authors of this review, believe that GSCs are the driving force behind GBM relapses, whereas others however, question the existence of GSCs. Evidence has accumulated indicating that non-tumorigenic cancer cells with high heterogeneity, could undergo reprogramming and become GSCs. Hence, targeting GSCs as the "root cells" initiating malignancy has been proposed to eradicate this devastating disease. Most standard treatments fail to completely eradicate GSCs, which can then cause the recurrence of the disease. To effectively tar...Continue Reading

Citations

Aug 20, 2019·Current Pharmaceutical Design·Qingzhu YangHuanjie Yang
Jul 28, 2020·Biomarkers in Medicine·Xuezhi HuFangcheng Zhang
May 14, 2020·Molecular Cancer·Tianyi WangShaoqing Ju
Jun 17, 2020·Stem Cells Translational Medicine·Adriana BajettoTullio Florio
Nov 30, 2020·European Journal of Pharmacology·Andrzej HudeckiMarek J Łos
Nov 15, 2020·International Journal of Molecular Sciences·Alja ZottelRadovan Komel
Feb 13, 2021·Frontiers in Oncology·Arnaud LombardNatacha Coppieters
Mar 6, 2021·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Tijana StankovićMilica Pešić

Related Concepts

Antineoplastic Agents
Glioblastoma Multiforme
Neoplasm Metastasis
Neoplasm Recurrence, Local
Neoplastic Colony-Forming Units
Malignant Neoplasms
Classification
Glioblastoma
Neoplasms
Stem Cells

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