PMID: 7537631Jan 1, 1994Paper

Glioblastoma therapy by direct intralesional administration of I-131 radioiodine labeled antitenascin antibodies

Cell Biophysics
P RivaF Campori

Abstract

Thirty patients with recurrent glioblastomas (29 brain, 1 spinal cord) received intralesional radioimmunotherapy aiming to control the progression of the tumor after surgery and radiotherapy. The BC-2 and/or BC-4 murine MAbs (Sorin-Biomedica, Saluggia, Italy) were utilized. They strongly react against tenascin (TN), which is an extracellular antigen expressed in large amounts by the stroma of glioblastoma but not by normal brain. The MAbs were labeled with I-131 and were injected directly into the tumor mass to maximize the antibody concentration in the tumor and to irradiate the neoplastic cells. The dose consisted, on average, of 3 mg antibody and 1100 MBq I-131. In most cases the radioimmunotherapy (RIT) applications were repeated two, three, or four times. No systemic adverse reactions were recorded. The brain tolerance to direct antibodies injection was quite good. The antibody concentration in the tumor was high and the MAb residence time in neoplastic tumor was prolonged. Consequently the mean radiation dose to the tumor was high: > 25,000 cGy/cycle. Of 23 evaluable patients, we recorded 7 tumor stabilization (lasting, on mean, 9.1 mo), 4 partial remission (10 mo), and 4 complete remission (18 mo). The overall response r...Continue Reading

References

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Citations

Sep 19, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Marta PedrettiSven Hillinger
Sep 29, 1999·Journal of Neuroscience Research·M Alvarez-DoladoA Muñoz
Jul 30, 2019·Frontiers in Pharmacology·Clément BaillyMickaël Bourgeois
Apr 14, 2019·Acta neurochirurgica·Hans-Jürgen ReulenWalter Stummer
May 22, 2004·Cancer Control : Journal of the Moffitt Cancer Center·Moneeb EhteshamJohn S Yu
Aug 3, 2021·Experimental Cell Research·Pritam Kumar RoyMahitosh Mandal

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