PMID: 16613313Apr 15, 2006Paper

Glioma assessment using quantitative blood volume maps generated by T1-weighted dynamic contrast-enhanced magnetic resonance imaging: a receiver operating characteristic study

Acta Radiologica
L LüdemannC Zimmer

Abstract

To investigate the use of blood volume maps in the non-invasive separation of glioma grades. T1-weighted quantitative dynamic contrast-enhanced magnetic resonance imaging was used to quantify the fractional intratumoral blood volume of 41 gliomas (World Health Organization (WHO) grades II-IV). Two methods, mean fractional intratumoral blood volume determination and a system based on thresholds for extracting the tumor pixels with the highest vascularization from the blood volume maps, were investigated by means of receiver operating characteristic (ROC) analysis. The thresholds were adjusted using the ROC curve area calculated using the trapezoid method. The ability to separate grade II (WHO) gliomas from grades III-IV was nearly the same for both methods (ROC curve area 0.941 (threshold) versus 0.932 (mean value)) and significantly greater than the ability to separate grade IV (WHO) gliomas from grades II-III (ROC curve area 0.792 (threshold) versus 0.787 (mean value)). The best correspondence with WHO glioma grading was achieved using thresholds corresponding to only the 5.2% of tumor voxels with the largest blood volume for separating grade II gliomas and 4% for separating grade IV gliomas. Use of the optimized threshold res...Continue Reading

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Citations

Oct 27, 2009·Journal of Magnetic Resonance Imaging : JMRI·Riham H El KhouliDavid A Bluemke
Jan 25, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Lutz LüdemannJohanna Gellermann
May 15, 2007·Health Physics·Peter WustJohanna Gellermann
Jan 23, 2016·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Yi Pang, Kelly A Frantz
Jul 30, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jeremiah W SandersHo-Ling Liu
Jun 16, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adriana TomicMark M Davis
Apr 10, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Robert LorentssonMagnus Båth
Aug 24, 2020·Journal of Pediatric Urology·Akram E ElSadekOmima M Abdel Haie

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