Glioma Indian scenario: Is there a human leucocyte antigen association?

Journal of Natural Science, Biology, and Medicine
U Shankarkumar, B Sridharan

Abstract

The central nervous system tumors are a rare neoplasm with little knowledge with Human Leukocyte Antigen (HLA) involvement. Primary brain tumors are cancers that originate in brain classified according to their appearance under a microscope as low grade (grade I and II) with diffuse astrocytomas, pliocytic astrocytomas, oligodendrogliomas, gangliogliomas, and mixed gliomas as common subtypes and high grade (grade III and IV). HLA associations in common glioma are reported from other parts of the world. The normal cancer treatment is surgery, followed by radiotherapy, and chemotherapy; nowadays immunotherapy is advised. HLA distribution in a Glioma patient was done based on serology and molecular techniques. The immune response gene studies have implicated the HLA allele association in most of the common diseases from India. Considerable variations are noted in HLA association with cancers; hence, we have summarized the HLA involvement in Glioma with respect to the literature. HLA A*030101, A*310102, B*350101, B*4406, Cw*040101, Cw*070101, DRB1*070101, and DRB1*1001. Ethnic diversity and HLA polymorphism precipitate differential immune response genes involved in variable disease manifestations. Therefore, caste-specific HLA alle...Continue Reading

Citations

Mar 11, 2016·Indian Journal of Cancer·P Mahalakshmi, A J Vanisree
May 10, 2017·Omics : a Journal of Integrative Biology·Kishore GollapalliSanjeeva Srivastava
Apr 21, 2020·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Ning SunCun-Zhi Liu
Apr 5, 2017·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Pacharee ManoySittisak Honsawek
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