Glioma infiltration sign on high b-value diffusion-weighted imaging in gliomas and its prognostic value

Journal of Magnetic Resonance Imaging : JMRI
Qiang ZengJianmin Zhang

Abstract

Glioma cells may infiltrate beyond the tumor margins revealed on conventional structural images. To investigate whether the presence of a glioma infiltration sign on high b-value diffusion-weighted imaging (DWI) can predict the prognosis of gliomas. Retrospective cohort. Fifty-two patients with gliomas (14 WHO grade II; 13 WHO grade III; 25 WHO grade IV). 3.0T, including a T1-weighted contrast-enhanced (T1w-CE) sequence, contrast-enhanced T2-flair sequence, and a DWI sequence. T1w-CE images and contrast-enhanced T2-flair images were used for identifying the tumor region for enhancing and nonenhancing gliomas, respectively. The glioma infiltration sign was defined as the presence of a peritumoral abnormal high signal region on DWI map, which was adjacent to the tumor region and had higher signal than surrounding areas. This sign was assessed on a high b-value DWI map with b = 3000 s/mm2. For patients with glioma infiltration sign, DWI3000max, DWI1000max, ADC3000min, and ADC1000minwere measured by drawing a region of interest over the peritumoral abnormal high signal region. Survival analysis was conducted by using Cox regression. Glioma infiltration sign was observed in 28 (53.8%) patients. The occurrence rate of this sign was 9...Continue Reading

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Apr 27, 2018·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Whitney B Pope, Garth Brandal
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