Gliotransmission: Exocytotic release from astrocytes.

Brain Research Reviews
Vladimir Parpura, Robert Zorec

Abstract

Gliotransmitters are chemicals released from glial cells fulfilling a following set of criteria: (i) they are synthesized by and/or stored in glia; (ii) their regulated release is triggered by physiological and/or pathological stimuli; (iii) they activate rapid (milliseconds to seconds) responses in neighboring cells; and (iv) they play a role in (patho)physiological processes. Astrocytes can release a variety of gliotransmitters into the extracellular space using several different mechanisms. In this review, we focus on exocytotic mechanism(s) underlying the release of three classes of gliotransmitters: (i) amino acids, such as, glutamate and d-serine; (ii) nucleotides, like adenosine 5'-triphosphate; and (iii) peptides, such as, atrial natriuretic peptide and brain-derived neurotrophic factor. It is becoming clear that astrocytes are endowed with elements that qualify them as cells communicating with neurons and other cells within the central nervous system by employing regulated exocytosis.

References

Aug 1, 1988·Journal of Neuroscience Research·H Pasantes Morales, A Schousboe
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·M J SchellS H Snyder
Jun 30, 1994·Nature·V ParpuraP G Haydon
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J H Jiao, A J Baertschi
May 26, 1998·Brain Research. Brain Research Reviews·P B Simpson, J T Russell
Sep 30, 1998·The European Journal of Neuroscience·A AraqueP G Haydon
Dec 2, 1998·The Journal of Immunology : Official Journal of the American Association of Immunologists·J M SoosS S Zamvil
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·M L CotrinaM Nedergaard
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·H WoloskerS H Snyder
Jul 31, 1999·The Journal of Biological Chemistry·F CalegariP Rosa
Jul 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·V Parpura, P G Haydon
Oct 23, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J C McKenzieR M Klein
Oct 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert T FremeauRobert H Edwards
Nov 5, 2002·The Journal of Biological Chemistry·Silvia CocoClaudia Verderio
Jun 28, 1954·The Journal of Physiology·J DEL CASTILLO, B KATZ
Dec 13, 2003·Cell Calcium·Andreas BeckJoachim W Deitmer
Jan 15, 2004·The Journal of Biological Chemistry·Qi ZhangPhilip G Haydon
Mar 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vedrana MontanaVladimir Parpura
Apr 20, 2004·Glia·Marko KreftRobert Zorec
May 25, 2004·Neuroscience Research·Alexander WilhelmHerbert Zimmermann
Jun 8, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Matjaz StenovecRobert Zorec
Jun 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Qi ZhangPhilip G Haydon
Mar 2, 2005·Biochemical and Biophysical Research Communications·Maja PotokarRobert Zorec
Apr 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jean-Pierre MothetGérard Baux
Jul 19, 2005·Nature Reviews. Neuroscience·Andrea Volterra, Jacopo Meldolesi
Oct 7, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiaoke ChenZhuan Zhou
Jan 13, 2006·Journal of Neurochemistry·Sara StiglianiGiambattista Bonanno
May 23, 2006·Nature Reviews. Neuroscience·R Douglas Fields, Geoffrey Burnstock
Sep 29, 2006·Glia·Vedrana MontanaVladimir Parpura
Jan 19, 2007·Traffic·Maja PotokarRobert Zorec
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·David N Bowser, Baljit S Khakh
Apr 27, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nina VardjanRobert Zorec
Jun 23, 2007·The Journal of Biological Chemistry·Jun XuJian Kang
Jul 10, 2007·Nature Cell Biology·Zhijun ZhangShumin Duan

❮ Previous
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Citations

Mar 29, 2012·Journal of Computational Neuroscience·Shivendra Tewari, Kaushik Majumdar
Jun 5, 2013·Journal of Biological Physics·Shivendra G Tewari, Kaushik Kumar Majumdar
May 21, 2013·Neurochemistry International·Helen E Scharfman, Devin K Binder
Aug 10, 2010·Acta Pharmacologica Sinica·Alexei Verkhratsky, Vladimir Parpura
Jul 29, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ana PocivavsekRobert Schwarcz
Sep 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jerome ClasadonteVincent Prevot
Aug 7, 2010·Brain : a Journal of Neurology·Romain MarignierPascale Giraudon
Dec 8, 2011·Cold Spring Harbor Perspectives in Biology·Pablo E Castillo
Jan 30, 2013·Molecular Brain·Mika TanakaShigeyoshi Itohara
Dec 14, 2011·PLoS Computational Biology·Maurizio De PittàEshel Ben-Jacob
Jan 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jan E Melom, J Troy Littleton
Apr 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vanessa A SkucasHelen E Scharfman
Jun 10, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luciano MarpeganChristian Beaulé
Jul 25, 2013·Journal of Molecular Endocrinology·Carla CarusoMercedes Lasaga
Jan 1, 2013·Croatian Medical Journal·Vladimir Parpura, Alexei Verkhratsky
Dec 27, 2013·Neural Plasticity·Yusuke OtaRobert M Hallock
Oct 4, 2013·Neural Plasticity·Francesco Ferrini, Yves De Koninck
May 9, 2014·Nature Communications·Priyanka SinghRobert Zorec
Sep 17, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Marta NavarreteAlfonso Araque
Oct 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yvonne SchmitzDavid Sulzer
Dec 12, 2012·Cellular and Molecular Life Sciences : CMLS·Marko KreftRobert Zorec
Apr 6, 2012·Neurochemical Research·Alexei VerkhratskyVladimir Parpura
Apr 25, 2012·Neurochemical Research·Alenka GučekRobert Zorec
May 29, 2012·Neurochemical Research·C-Y ChiangJ O Dostrovsky
Jan 4, 2013·Neurochemical Research·Ana Sofia FalcãoDora Brites
May 4, 2011·The Journal of Cell Biology·Ilaria PradaJacopo Meldolesi
Jun 15, 2011·FEBS Letters·Miquel Barceló-TornsRoser Masgrau
Nov 12, 2015·Brain Injury : [BI]·Daniel SimonAndrea Regner
Feb 10, 2016·Journal of Neural Transmission·Renata Basso CupertinoNina Roth Mota
Dec 19, 2015·Cellular and Molecular Life Sciences : CMLS·Chiara SimoneStefania Corti
Dec 29, 2015·Current Opinion in Pharmacology·Francesco Petrelli, Paola Bezzi

❮ Previous
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