Glipizide-GITS does not increase the hypoglycemic effect of mild exercise during fasting in NIDDM

Diabetes Care
M C RiddleL A Tive

Abstract

This study compared the effect of mild exercise while fasting on plasma glucose concentrations in subjects with NIDDM treated with extended-release glipizide and subjects not taking an oral hypoglycemic agent. Twenty-five moderately obese subjects with NIDDM were randomized to treatment with extended-release glipizide or placebo. After 9 weeks of treatment, they fasted overnight, took their study drug, omitted breakfast, and exercised on a treadmill for 90 min. Glucose, insulin, and C-peptide concentrations were measured before, during, and after exercise. On the fasting-exercise day, fasting glucose concentrations were lower (153 vs. 241 mg/dl, P < 0.01) and insulin and C-peptide concentrations higher in the extended-release glipizide group. The decrement of glucose from the fasting baseline was modest and equivalent in the two groups: 17 vs. 21 mg/dl at the end of exercise and 28 vs. 27 mg/dl after 2 h of recovery. No subject had hypoglycemic symptoms. Chronic use of extended-release glipizide does not enhance the hypoglycemic effect of fasting plus mild exercise for people with NIDDM. Routine lifestyle treatments for NIDDM may be continued during ongoing use of this agent.

Citations

Jun 23, 1999·British Journal of Sports Medicine·N S Peirce
May 19, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Henrik GalboLuc J C van Loon
Dec 5, 2012·Annals of Nutrition & Metabolism·Jonida HaxhiMassimo Sacchetti
May 30, 2009·Acta Diabetologica·Stephan F E Praet, Luc J C van Loon
Mar 3, 2007·Journal of Diabetes and Its Complications·Jan SzewieczekGrzegorz Kawecki
Apr 30, 2005·Diabetes Research and Clinical Practice·M FeinglosI Kourides
Oct 16, 1999·Primary Care·B LunaM N Feinglos
Nov 29, 2007·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Thierry Gaudet-SavardPaul Poirier
Jul 28, 2001·Medicine and Science in Sports and Exercise·P PoirierA Nadeau

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