PMID: 6988265Jan 1, 1980Paper

Glipizide versus tolbutamide, an open trial. Effects on insulin secretory patterns and glucose concentrations

Diabetologia
S E Fineberg, S H Schneider

Abstract

An open parallel trial with glipizide or tolbutamide was carried out in a cohort of 29 comparable maturity-onset diabetic patients. Eighteen of these individuals were studied in detail. During six months of active drug therapy the mean decrease in fasting serum glucose levels on glipizide was 25 +/- 2% versus 17 +/- 2% on tolbutamide (p less than 0.025). Decreases in post prandial glucose levels were 12.2 and 10.4%. Glucose disappearance rates (Kg) during the sixth month of treatment with both drugs increased significantly: on glipizide from 0.47 +/- 0.04%/min to 0.85 +/- 0.08%/min(p less than 0.005), and on tolbutamide from 0.47 +/- 0.08%/min to 0.70 +/- 0.11%/min (p less than 0.01). Early and late insulin release (summed increases over basal for 2--10 min and 10--60 min) during intravenous glucose tolerance testing increased during glipizide, but not during tolbutamide therapy. Post prandial insulin increments over basal during an oral glucose tolerance test also increased during glipizide, but not tolbutamide therapy. Both drugs were comparable with regard to efficacy and safety; however, only glipizide had chronic effects upon insulin secretion.

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Citations

Jan 1, 1991·European Journal of Clinical Pharmacology·A E PontiroliG Pozza
Feb 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·H C SimpsonJ P Reckless
Jul 1, 1989·The American Journal of the Medical Sciences·G Wensing
Oct 1, 1990·Diabetes Research and Clinical Practice·J Cederholm, L Wibell
Jan 17, 1983·The American Journal of Medicine·R A DeFronzoV Koivisto
Apr 1, 1997·Pediatric Clinics of North America·N S Glaser
Apr 1, 1994·Diabetic Medicine : a Journal of the British Diabetic Association·M J DaviesI P Gray
Nov 2, 1989·The New England Journal of Medicine·J E Gerich
Jul 30, 2015·The Cochrane Database of Systematic Reviews·Bianca HemmingsenThomas P Almdal
Apr 1, 1991·Journal of Endocrinological Investigation·D GulloF Purrello

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