Global abnormalities in lymphatic function following systemic therapy in patients with breast cancer

The British Journal of Surgery
S K BainsArnie D Purushotham

Abstract

Breast cancer-related lymphoedema (BCRL) is a result of interaction between several pathophysiological processes, and is not simply a 'stopcock' effect resulting from removal of axillary lymph nodes. The aim of this study was to test the hypothesis that there is a constitutional 'global' lymphatic dysfunction in patients who develop BCRL. Lower-limb lymphoscintigraphy was performed in 30 women who had undergone axillary lymph node dissection at least 3 years previously, of whom 15 had BCRL and 15 did not. No patient had any clinical abnormality of the lower limb. The control group comprised 24 women with no history of cancer or lower-limb lymphoedema. (99m) Tc-Nanocoll was injected subcutaneously into the first webspace of each foot, followed by whole-body imaging. Scans were reported as abnormal if there was delay in lymph transport or rerouting through skin or deep system. Quantification was expressed as the percentage injected activity accumulating in ilioinguinal nodes. Mean(s.d.) ilioinguinal nodal accumulation at 150 min was significantly lower in women with BCRL than in those without (2·7(2·5) versus 5·9(4·8) per cent respectively; P = 0·006). Abnormal findings on lower-limb lymphoscintigraphy were observed in 17 of the ...Continue Reading

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Citations

Jun 5, 2015·The British Journal of Surgery·M CariatiA D Purushotham
Mar 28, 2017·Lymphatic Research and Biology·Zeynep Erdogan IyigunVahit Ozmen
Feb 2, 2017·Nuclear Medicine Communications·Georgia KeramidaA Michael Peters
May 21, 2017·The Journal of Investigative Dermatology·Epameinondas GousopoulosMichael Detmar
Mar 12, 2019·Annals of Plastic Surgery·Anna Rose JohnsonDhruv Singhal
Aug 18, 2021·Journal of Vascular Surgery. Venous and Lymphatic Disorders·A Michael Peters, Peter S Mortimer

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