Global analysis of della direct targets in early gibberellin signaling in Arabidopsis.

doi:10.1105/tpc.107.054999

PMID: 17933900DOI: 10.1105/tpc.107.054999Oct 16, 2007Paper

Global analysis of della direct targets in early gibberellin signaling in Arabidopsis.

The Plant Cell

Rodolfo ZentellaTai-Ping Sun

Abstract

Bioactive gibberellins (GAs) are phytohormones that regulate growth and development throughout the life cycle of plants. DELLA proteins are conserved growth repressors that modulate all aspects of GA responses. These GA-signaling repressors are nuclear localized and likely function as transcriptional regulators. Recent studies demonstrated that GA, upon binding to its receptor, derepresses its signaling pathway by binding directly to DELLA proteins and targeting them for rapid degradation via the ubiquitin-proteasome pathway. Therefore, elucidating the signaling events immediately downstream of DELLA is key to our understanding of how GA controls plant development. Two sets of microarray studies followed by quantitative RT-PCR analysis allowed us to identify 14 early GA-responsive genes that are also early DELLA-responsive in Arabidopsis thaliana seedlings. Chromatin immunoprecipitation provided evidence for in vivo association of DELLA with promoters of eight of these putative DELLA target genes. Expression of all 14 genes was downregulated by GA and upregulated by DELLA. Our study reveals that DELLA proteins play two important roles in GA signaling: (1) they help establish GA homeostasis by direct feedback regulation on the e...Continue Reading

Associated Datasets

Early gibberellin responses and DELLA protein direct targets in Arabidopsis

Nov 21, 2007

Early gibberellin responses in Arabidopsis

Nov 21, 2007

DELLA protein direct targets in Arabidopsis

Nov 21, 2007

Transcription profiling by array of Arabidopsis mutant for ga1 treated with GA4 or expressing rga-delta17 treated with GA4 and dexamethasone

Jun 16, 2008·Rodolfo Zentella

Transcription profiling by array of Arabidopsis mutant for ga1 after treatment with GA4

Jun 16, 2008·Rodolfo Zentella

Transcription profiling by array of Arabidopsis with DEX-inducible construct carrying rga-delta17 after treatment with dexamethasone

Jun 16, 2008·Rodolfo Zentella

Early gibberellin responses and DELLA protein direct targets in Arabidopsis

Aug 15, 2007

Early gibberellin responses in Arabidopsis

Aug 9, 2007

DELLA protein direct targets in Arabidopsis

Aug 9, 2007

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