PMID: 25749033Mar 10, 2015Paper

Global analysis of H3K4me3 and H3K27me3 profiles in glioblastoma stem cells and identification of SLC17A7 as a bivalent tumor suppressor gene

Oncotarget
Biaoyang LinCharles Cobbs

Abstract

Epigenetic changes, including H3K4me3 and H3K27me3 histone modification, play an important role in carcinogenesis. However, no genome-wide histone modification map has been generated for gliomas. Here, we report a genome-wide map of H3K4me3 and H3K27me3 histone modifications for 8 glioma stem cell (GSC) lines, together with the associated gene activation or repression patterns. In addition, we compared the genome-wide histone modification maps of GSC lines to those of astrocytes to identify unique gene activation or repression profiles in GSCs and astrocytes. We also identified a set of bivalent genes, which are genes that are associated with both H3K4me3 and H3K27me3 marks and are poised for action in embryonic stem cells. These bivalent genes are potential targets for inducing differentiation in glioblastoma (GBM) as a therapeutic approach. Finally, we identified SLC17A7 as a bivalent tumor suppressor gene in GBM, as it is down-regulated at both the protein and RNA levels in GBM tissues compared with normal brain tissues, and it inhibits GBM cell proliferation, migration and invasion.

References

Jun 9, 2001·Molecular Carcinogenesis·S MaegawaM Oshimura
Sep 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Luigi MarianiMichael M Reinert
Oct 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tae-Young RohKeji Zhao
Jul 3, 2007·Nature·Tarjei S MikkelsenBradley E Bernstein
Feb 6, 2008·Nature Reviews. Genetics·Dustin E Schones, Keji Zhao
Oct 10, 2009·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xin LiuJoseph J Y Sung
Feb 6, 2010·Neuropathology and Applied Neurobiology·M QuM Nistér
Feb 26, 2010·Genome Research·Reena BhandareKlaus H Kaestner
Mar 26, 2010·Nature·Nadine L VastenhouwAlexander F Schier
Nov 4, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Maria S IliouManel Esteller

❮ Previous
Next ❯

Citations

Apr 10, 2019·BMC Bioinformatics·Garrett JenkinsonJohn Goutsias
May 22, 2019·International Journal of Molecular Sciences·Fiona M Frame, Norman J Maitland
Jan 11, 2020·Artificial Cells, Nanomedicine, and Biotechnology·Ying LiYijian Chen
Nov 11, 2015·EMBO Reports·Arigela Harikumar, Eran Meshorer
Feb 25, 2017·Molecular Cancer·Michael RoseEdgar Dahl
Jun 27, 2019·Proceedings of the National Academy of Sciences of the United States of America·Merrin Man Long LeongMaria Li Lung
May 23, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Judit SymmankGeraldine Zimmer-Bensch
Dec 17, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Yangmei ZhangLong Cheng
Nov 5, 2020·The Journal of Clinical Endocrinology and Metabolism·Ying-Ting WuHui-Fen Chen
Dec 22, 2020·Frontiers in Oncology·Luis M Valor, Irati Hervás-Corpión
Jan 13, 2021·International Journal of Molecular Sciences·Mariam MarkouliChristina Piperi
Jul 25, 2021·Cancers·Dimitris Karagiannis, Theodoros Rampias
Aug 10, 2021·Briefings in Bioinformatics·Chayanit PiyawajanusornPedro J Ballester
Aug 22, 2021·Stem Cell Reviews and Reports·Han SunLisha Li
Dec 24, 2021·Frontiers in Cell and Developmental Biology·Rahim Hassanaly-GoulamhoussenLaetitia Perfus-Barbeoch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.