Global analysis of iron assimilation and fur regulation in Yersinia pestis

FEMS Microbiology Letters
Dongsheng ZhouRuifu Yang

Abstract

Using DNA microarray analysis, mRNA levels from wild-type Yersinia pestis cells treated with the iron chelator 2,2'-dipyridyl were compared with those supplemented with excessive iron, and subsequent to this, gene expression in the fur mutant was compared with that in the wild-type strain under iron rich conditions. The microarray analysis revealed many iron transport or storage systems that had been induced in response to the iron starvation, which is mediated by the Fur protein, using the iron as a co-repressor. The iron-Fur complex also affected some genes involved in various non-iron functions (ribonucleoside-diphosphate reductase, membrane proteins, electron transport and oxidative defense, etc.). The Fur protein still participated in the regulation of genes involved in broad cellular processes (virulence factors, pesticin activity, haemin storage and many proteins with unknown functions) that were not affected by iron depletion conditions. In addition to its classical negative regulatory activities, the Fur protein activates gene transcription. Using bioinformatics tools, we were able to predict the Y. pestis Fur box sequence that was clearly the over-presented motif in the promoter regions of members of the iron-Fur modu...Continue Reading

References

Oct 25, 1990·Nucleic Acids Research·T D Schneider, R M Stephens
Oct 1, 1995·Infection and Immunity·T F De Koning-Ward, R M Robins-Browne
Dec 1, 1994·Journal of Bacteriology·T M StaggsR D Perry
Dec 13, 1996·Biochemical and Biophysical Research Communications·M A QuailJ R Guest
Jan 1, 1997·Clinical Microbiology Reviews·R D Perry, J D Fetherston
Jan 16, 1999·Advances in Microbial Physiology·S C Andrews
Jan 6, 2000·Archives of Biochemistry and Biophysics·D Touati
Jun 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·K A Datsenko, B L Wanner
Apr 3, 2001·Current Opinion in Microbiology·K Hantke
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Jun 22, 2001·Microbes and Infection·E Carniel
Feb 21, 2002·Infection and Immunity·Yidong DuAke Forsberg
May 23, 2002·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Gert ThijsYves Moreau
Oct 2, 2002·Molecular Microbiology·Noel BaichooJohn D Helmann
Oct 11, 2002·Journal of Bacteriology·Noel Baichoo, John D Helmann
May 15, 2003·The Journal of Biological Chemistry·Jonathan P McHughSimon C Andrews
Jun 5, 2003·Trends in Microbiology·Klaus Hantke
Jun 24, 2003·Infection and Immunity·Robert D PerryJacqueline D Fetherston
Jun 28, 2003·FEMS Microbiology Reviews·Simon C AndrewsFrancisco Rodríguez-Quiñones
Sep 17, 2004·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Yajun SongRuifu Yang
Oct 19, 2004·Annual Review of Microbiology·Cécile Wandersman, Philippe Delepelaire
Oct 21, 2004·International Journal of Medical Microbiology : IJMM·Sören SchubertJürgen Heesemann
Feb 3, 2005·FEMS Microbiology Letters·Jingfu QiuRuifu Yang
Aug 3, 2005·FEMS Microbiology Letters·Dongsheng ZhouRuifu Yang

❮ Previous
Next ❯

Citations

May 25, 2010·Journal of Bacteriology·Laura J Runyen-JaneckyRita V M Rio
Aug 14, 2012·Journal of Bacteriology·Chunxiao Yu, Caroline Attardo Genco
Oct 27, 2009·Journal of Bacteriology·Lydgia A JacksonDavid W Dyer
Feb 19, 2008·Journal of Bacteriology·He GaoRuifu Yang
Aug 30, 2011·Journal of Bacteriology·Jonathan D LenzVirginia L Miller
Dec 19, 2006·PLoS Computational Biology·Dmitry A RodionovAndrew W B Johnston
Mar 14, 2012·PLoS Genetics·Biliana LesicElisabeth Carniel
Jan 4, 2013·PloS One·Fengjun SunRuifu Yang
Jan 1, 2008·Indian Journal of Pharmacology·Henrique Douglas Melo CoutinhoInalzuir Lôbo
Jul 16, 2013·Antonie van Leeuwenhoek·Gustavo Pelicioli RiboldiJeverson Frazzon
Feb 18, 2016·Biochemistry·Julien PérardEve de Rosny
Dec 1, 2012·Comparative Immunology, Microbiology and Infectious Diseases·Gabriela Mellado-SanchezMarcela F Pasetti
Mar 15, 2016·Frontiers in Cellular and Infection Microbiology·Shiyun ChenMatthew S Francis
Nov 2, 2011·Journal of Proteomics·Lei ZhouXiaohong Qian
Mar 27, 2007·Current Opinion in Microbiology·Jonathan Livny, Matthew K Waldor
Dec 17, 2008·Journal of Medical Microbiology·Andrey P AnisimovSvetlana V Dentovskaya
Feb 5, 2015·BMC Microbiology·Sunniva Katharina ThodePeik Haugen
Aug 9, 2017·Frontiers in Cellular and Infection Microbiology·Lauren O'ConnorRobert D Perry
Nov 3, 2017·Acta Crystallographica. Section D, Structural Biology·Christopher D RadkaStephen G Aller
Aug 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·V KalidasanVasantha Kumari Neela
Apr 27, 2021·Computational and Structural Biotechnology Journal·Miguel A MatillaTino Krell
Jul 20, 2021·Journal of Bacteriology·Peng LiWei Sun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.