Global assays and the management of oral anticoagulation

Thrombosis Journal
Herm Jan M Brinkman

Abstract

Coagulation tests range from global or overall tests to assays specific to individual clotting factors and their inhibitors. Whether a particular test is influenced by an oral anticoagulant depends on the principle of the test and the type of oral anticoagulant. Knowledge on coagulation tests applicable in monitoring status and reversal of oral anticoagulation is a prerequisite when studying potential reversal agents or when managing anticoagulation in a clinical setting. Specialty tests based on the measurement of residual activated factor X (Xa) or thrombin activity, e.g., are highly effective for determining the concentration of the new generation direct factor Xa- and thrombin inhibitors, but these tests are unsuitable for the assessment of anticoagulation reversal by non-specific prohemostatic agents like prothrombin complex concentrate (PCC) and recombinant factor VIIa (FVIIa). Global coagulation assays, in this respect, seem more appropriate. This review evaluates the current status on the applicability of the global coagulation assays PT, APTT, thrombin generation and thromboelastography in the management of oral anticoagulation by vitamin K antagonists and the direct factor Xa and thrombin inhibitors. Although all glob...Continue Reading

References

Dec 1, 1986·Drug Intelligence & Clinical Pharmacy·V M Hauser, S L Rozek
Feb 13, 1996·Biochemistry·S Butenas, K G Mann
Jun 1, 1997·Thrombosis Research·B PötzschG Müller-Berghaus
Dec 11, 1999·JAMA : the Journal of the American Medical Association·S S Anand, S Yusuf
Oct 29, 2000·Thrombosis Research·E Lindhoff-LastR Bauersachs
Sep 1, 2001·British Journal of Haematology·P M Mannucci, L Poller
Oct 31, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·M J KemmeJ Burggraaf
Oct 24, 2002·Journal of Clinical Anesthesia·David L HepnerKodali Bhavani-Shankar
Jan 14, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Kenneth G MannKathleen Brummel
Jul 11, 2003·Pathophysiology of Haemostasis and Thrombosis·H Coenraad HemkerSuzette Béguin
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·K G MannS Butenas
Jan 1, 1959·Circulation·K P LINK
Sep 1, 2005·Transfusion·Jodi B SegalUNKNOWN Transfusion Medicine/Hemostasis Clinical Trials Network
Jan 18, 2006·Journal of Thrombosis and Haemostasis : JTH·T LivnatU Seligsohn
Nov 3, 2006·Thrombosis and Haemostasis·H Coenraad HemkerSuzette Béguin
Jan 9, 2007·Blood Reviews·Alisa S Wolberg
Jan 25, 2008·Thrombosis and Haemostasis·Francis CouturaudUNKNOWN Groupe d'Etude de la Thrombose de Bretagne Occidentale (G.E.T.B.O)
Mar 22, 2008·British Journal of Haematology·Douglas Wardrop, David Keeling
Mar 29, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·T LivnatU Seligsohn
Aug 12, 2008·International Journal of Clinical Practice·U KalinaS Schulte
Feb 6, 2010·Thrombosis and Haemostasis·Meyer Michel SamamaElisabeth Perzborn
Jul 9, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·A S Wolberg
Jul 31, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Wolfgang G EisertJoanne van Ryn
Oct 16, 2010·Journal of Thrombosis and Haemostasis : JTH·A HillarpT L Lindahl
Nov 26, 2010·Thrombosis and Haemostasis·Tomas L LindahlUNKNOWN Expert Group on Coagulation of the External Quality Assurance in Laboratory Medicine in Sweden
Dec 18, 2010·Nature Reviews. Drug Discovery·Elisabeth PerzbornFrank Misselwitz
Feb 15, 2011·Journal of Thrombosis and Thrombolysis·Pancras C WongDonglu Zhang
Jun 16, 2011·British Journal of Haematology·David KeelingUNKNOWN British Committee for Standards in Haematology
Oct 11, 2011·Journal of Thrombosis and Haemostasis : JTH·R Al DieriH C Hemker
Oct 12, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Job HarenbergChristel Weiss

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Citations

Oct 17, 2015·Expert Review of Cardiovascular Therapy·Noel C ChanJohn W Eikelboom
Feb 3, 2015·Thrombosis Journal·Mikhail A Panteleev, Hendrik Coenraad Hemker
Sep 24, 2016·Critical Care : the Official Journal of the Critical Care Forum·Karen S BrownJerrold H Levy
Jul 26, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Barbora KorpallováMarián Mokáň
Dec 7, 2016·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Andrew C FaustAnn K Wittkowsky
Mar 13, 2019·Journal of Veterinary Internal Medicine·Junwoo BaeDohyeon Yu
Oct 16, 2019·Advanced Healthcare Materials·Steffen BrauneFriedrich Jung
Sep 15, 2019·Journal of Thrombosis and Thrombolysis·Maria Cristina VedovatiCecilia Becattini
Mar 7, 2020·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Anica PetkovicJovan P Antovic
May 25, 2018·Scandinavian Journal of Clinical and Laboratory Investigation·Caroline U NilssonPeter Reinstrup
Jun 13, 2020·The Journal of Applied Laboratory Medicine·Junhua ZhangFei Xiao
Apr 11, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·V F de ArandaJ C de Campos Guerra
Dec 29, 2020·International Journal of Laboratory Hematology·Geoffrey Foulon-PintoVirginie Siguret

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