Global assessment of the antimicrobial activity of polymyxin B against 54 731 clinical isolates of Gram-negative bacilli: report from the SENTRY antimicrobial surveillance programme (2001-2004)

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
A C GalesH S Sader

Abstract

In total, 54 731 Gram-negative bacilli isolated worldwide between 2001 and 2004 from diverse sites of infection were tested for susceptibility to polymyxin B by the broth reference microdilution method, with interpretation of results according to CLSI (formerly NCCLS) guidelines. Polymyxin B showed excellent potency and spectrum against 8705 Pseudomonas aeruginosa and 2621 Acinetobacter spp. isolates (MIC50, < or = 1 mg/L and MIC90, 2 mg/L for both pathogens). Polymyxin B resistance rates were slightly higher for carbapenem-resistant P. aeruginosa (2.7%) and Acinetobacter spp. (2.8%), or multidrug-resistant (MDR) P. aeruginosa (3.3%) and Acinetobacter spp. (3.2%), when compared with the entire group (1.3% for P. aeruginosa and 2.1% for Acinetobacter spp.). Among P. aeruginosa, polymyxin B resistance rates varied from 2.9% in the Asia-Pacific region to only 1.1% in Europe, Latin America and North America, while polymyxin B resistance rates ranged from 2.7% in Europe to 1.7% in North America and Latin America among Acinetobacter spp. Polymyxin B also demonstrated excellent activity (MIC90, < or = 1 mg/L; > 98% susceptible) against Citrobacter spp., Escherichia coli and Klebsiella spp., but activity was more variable against Enter...Continue Reading

References

Jun 1, 1977·Bacteriological Reviews·E Katz, A L Demain
Oct 2, 1979·Biochemistry·M Schindler, M J Osborn
Oct 1, 1984·Antimicrobial Agents and Chemotherapy·R A MooreR E Hancock
Feb 1, 1997·The Journal of Antimicrobial Chemotherapy·C R CatchpoleR Wise
Mar 28, 1998·Antimicrobial Agents and Chemotherapy·J J DrabickA S Cross
Aug 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A S LevinS F Costa
Apr 26, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A C GalesR Ramphal
Sep 16, 2003·Emerging Infectious Diseases·Adriana O ReisAna C Gales
Mar 1, 1956·Bacteriological Reviews·B A NEWTON
Jan 9, 2004·Infectious Disease Clinics of North America·Elizabeth D HermsenJohn C Rotschafer
Jun 19, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Patricia A BradfordJohn Quale
Oct 29, 2004·The Journal of Antimicrobial Chemotherapy·Michael HogardtJürgen Heesemann
Dec 29, 2004·International Journal of Antimicrobial Agents·Jian LiKingsley Coulthard
Apr 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew E Falagas, Sofia K Kasiakou
May 11, 2005·The Journal of Antimicrobial Chemotherapy·David LandmanJohn Quale

❮ Previous
Next ❯

Citations

Aug 9, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jian LiClare Franklin
May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rodrigo E MendesRonald N Jones
Oct 9, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alexandre P ZavasckiJian Li
Apr 26, 2008·The Journal of Antimicrobial Chemotherapy·Drosos E KarageorgopoulosMatthew E Falagas
Jan 17, 2009·The Journal of Antimicrobial Chemotherapy·Nobumasa AokiKeizo Yamaguchi
Aug 6, 2010·The Journal of Antimicrobial Chemotherapy·Laura S EliasAlexandre P Zavascki
Jun 2, 2009·The Pediatric Infectious Disease Journal·Pranita D Tamma, Carlton K Lee
Oct 3, 2009·Current Opinion in Infectious Diseases·Roger L Nation, Jian Li
Jun 17, 2009·Antimicrobial Agents and Chemotherapy·Mark D AdamsRobert A Bonomo
Sep 16, 2009·Antimicrobial Agents and Chemotherapy·Ji-Yoeun SuhJae-Hoon Song
Sep 22, 2010·Antimicrobial Agents and Chemotherapy·Jennifer H MoffattJohn D Boyce
Nov 3, 2010·Antimicrobial Agents and Chemotherapy·Carl UrbanJames J Rahal
Dec 12, 2007·Antimicrobial Agents and Chemotherapy·Christian G GiskeUNKNOWN ReAct-Action on Antibiotic Resistance
Jul 25, 2007·Antimicrobial Agents and Chemotherapy·Federico PerezRobert A Bonomo
Jul 16, 2008·Clinical Microbiology Reviews·David LandmanJohn Quale
Jul 16, 2008·Clinical Microbiology Reviews·Anton Y PelegDavid L Paterson
Jul 9, 2010·Clinical Microbiology Reviews·Matthijs C BrouwerDiederik van de Beek
Jul 25, 2012·Infection and Immunity·Leticia V BentancorTomás Maira-Litrán
Oct 11, 2008·Journal of Clinical Microbiology·Issmat I KassemVon Sigler
Oct 24, 2012·Annals of Clinical Microbiology and Antimicrobials·Liliana Fernández-Canigia, Michael J Dowzicky
Jan 17, 2008·Drugs·Jacob Gilad, Yehuda Carmeli
Sep 15, 2009·Drugs·Helen Giamarellou, Garyphallia Poulakou
May 20, 2011·The Libyan Journal of Medicine·Momen AskouraIbrahim Taher
Oct 12, 2010·Journal of Global Infectious Diseases·Vikas ManchandaNp Singh
May 17, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P PoulikakosM E Falagas
Mar 7, 2008·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Christian G GiskeBengt Wretlind
May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lisa L Maragakis, Trish M Perl
Aug 28, 2014·Critical Reviews in Microbiology·Jaime A LabarcaManuel Guzmán-Blanco
Oct 4, 2012·Expert Review of Anti-infective Therapy·Silpak BiswasJean-Marc Rolain
Oct 3, 2006·Expert Review of Anti-infective Therapy·Helen Giamarellou
Dec 18, 2009·Expert Review of Anti-infective Therapy·Alexandre P ZavasckiAna C Gales
May 2, 2008·Expert Opinion on Investigational Drugs·Zhe Yuan, Vincent H Tam
Feb 24, 2015·Current Medical Research and Opinion·Abed Zahedi Bialvaei, Hossein Samadi Kafil
Mar 14, 2016·Diagnostic Microbiology and Infectious Disease·Juliana Provasi CardosoAna Cristina Gales
Aug 13, 2011·Current Opinion in Pharmacology·Phillip J BergenRoger L Nation
Aug 2, 2014·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Hsin-Hao LaiChang-Phone Fung

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.