Global average gray and white matter N-acetylaspartate concentration in the human brain.

NeuroImage
Matilde IngleseO Gonen

Abstract

Since the amino acid derivative N-acetylaspartate (NAA) is almost exclusive to neuronal cells in the adult mammalian brain and its concentration has shown local (or global) abnormalities in most focal (or diffuse) neurological diseases, it is considered a specific neuronal marker. Yet despite its biological and clinical prominence, the relative NAA concentration in the gray and white matter (GM, WM) remains controversial, with each reported to be higher than, equal to, or less than the other. To help resolve the controversy and importantly, access the NAA in both compartments in their entirety, we introduce a new approach to distinguish and quantify the whole-brain average GM and WM NAA concentration by integrating MR-image segmentation, localized and non-localized quantitative (1)H-MRS. We demonstrate and validate the method in ten healthy volunteers (5 women) 27+/-6 years old (mean+/-standard-deviation) at 1.5T. The results show that the healthy adult human brain comprises significantly less WM, 39+/-3%, than GM 60+/-4% by volume (p<0.01). Furthermore, the average NAA concentration in the WM, 9.5+/-1.0 mM, is significantly lower than in GM, 14.3+/-1.1 mM (p<0.01).

References

Jun 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T J DoyleP A Narayana
Jan 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G TedeschiJ R Alger
Oct 1, 1993·Investigative Radiology·H Rusinek, R Chandra
Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B J SoherP B Barker
Jul 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H P HetheringtonG M Pohost
Mar 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K O Lim, D M Spielman
Oct 1, 1996·NMR in Biomedicine·D López-VillegasR E Lenkinski
Jan 23, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y Wang, S J Li
Jan 23, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·O GonenG Goelman
Oct 31, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·O GonenR I Grossman
Dec 5, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B J SoherA A Maudsley
Feb 20, 1999·Archives of General Psychiatry·A PfefferbaumK O Lim
Feb 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S M NoworolskiD B Vigneron
Mar 18, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A PfefferbaumK O Lim
Apr 27, 2001·The Anatomical Record·B Ross, S Bluml
Apr 27, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·N SchuffM W Weiner
Jul 11, 2001·Neurobiology of Aging·S De SantiJ Fowler
Jan 5, 2002·Annals of Neurology·D L ArnoldB D Trapp
Feb 12, 2002·Journal of Magnetic Resonance Imaging : JMRI·Declan T ChardDavid H Miller
Mar 1, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Belinda S Y LiOded Gonen
Apr 30, 2003·Neurochemical Research·Morris H Baslow
Jun 20, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Matilde IngleseOded Gonen
Jun 10, 2006·NMR in Biomedicine·Peter B KingsleyRona Woldenberg
Jun 13, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gadi GoelmanOded Gonen
Jun 29, 2006·Advances in Experimental Medicine and Biology·Norbert SchuffMichael W Weiner
Jul 26, 2006·Radiology·Jacobus F A JansenM Eline Kooi
Oct 20, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mary A McLean, Gareth J Barker
Feb 6, 2007·Progress in Neurobiology·John R MoffettAryan M A Namboodiri
May 31, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Wafaa ZaaraouiOded Gonen
Oct 9, 2007·AJNR. American Journal of Neuroradiology·D J RigottiO Gonen
May 28, 2008·Journal of Magnetic Resonance Imaging : JMRI·Artem MikheevHenry Rusinek

❮ Previous
Next ❯

Citations

Aug 14, 2009·Journal of the International Neuropsychological Society : JINS·Gerald GoldsteinJay W Pettegrew
Feb 19, 2011·Stroke; a Journal of Cerebral Circulation·Carmen M CirsteaRandolph J Nudo
May 12, 2012·Brain Research·Carmen M CirsteaWilliam M Brooks
Mar 8, 2011·Academic Radiology·Astrid E GramsElke R Gizewski
Feb 10, 2009·Journal of the Neurological Sciences·Declan Chard, David Miller
Jun 16, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C GasparovicN J Shah
Jun 10, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yan ZhangJun Shen
Apr 19, 2013·Clinical Endocrinology·Eugenia ResminiSusan M Webb
May 21, 2011·Glia·John R MoffettAryan M A Namboodiri
Mar 6, 2010·Annals of the New York Academy of Sciences·Stephanie C Licata, Perry F Renshaw
Feb 25, 2015·Magnetic Resonance Imaging·Christopher R DurstS Sendhil Velan
Apr 16, 2013·NeuroImage·Feliks KoganRavinder Reddy
Jul 6, 2017·NMR in Biomedicine·Ivan I KirovOded Gonen
Jun 15, 2013·Brain Sciences·Neena K SharmaCarmen M Cirstea
Aug 23, 2020·Translational Psychiatry·S E E C BauduinS J A van der Werff
Nov 7, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jing Cui, Zhongliang Zu
Jun 30, 2018·Neurology and Therapy·Maria PetraccaMatilde Inglese
Dec 7, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Anja FischerFritz Schick

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.

Related Papers

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Y Wang, S J Li
Progress in Neurobiology
John R MoffettAryan M A Namboodiri
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
H P HetheringtonG M Pohost
Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
N SchuffM W Weiner
© 2022 Meta ULC. All rights reserved