Global cell sorting is mediated by local cell-cell interactions in the C. elegans embryo

Developmental Biology
Marcus Bischoff, Ralf Schnabel

Abstract

The Caenorhabditis elegans embryo achieves pattern formation by sorting cells into coherent regions before morphogenesis is initiated. The sorting of cells is coupled to their fate. Cells move extensively relative to each other to reach their correct position in the body plan. Analyzing the mechanism of cell sorting in in vitro culture experiments using 4D microscopy, we show that all AB-derived cells sort only according to their local neighbors, and that all cells are able to communicate with each other. The directions of cell movement do not depend on a cellular polarity but only on local cell-cell interactions; in experimental situations, this allows even the reversal of the polarity of whole regions of the embryo. The work defines a new mechanism of pattern formation we call "cell focusing".

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Citations

Mar 28, 2008·Development·Thomas Keller, Christopher R L Thompson
Apr 18, 2012·Genome Research·John Isaac MurrayRobert H Waterston
Sep 17, 2013·PLoS Genetics·Jeffrey P RasmussenJames R Priess
Jul 4, 2012·EvoDevo·Jens SchulzeEinhard Schierenberg
Nov 3, 2007·Evolution & Development·Evan P KingsleyJ David Lambert
Nov 23, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Simon BlanchoudPierre Gönczy
Dec 12, 2012·Developmental Biology·Julia L RichardsJohn Isaac Murray
Jun 17, 2009·Developmental Biology·Jürgen HenchThomas R Bürglin
Apr 22, 2006·Developmental Biology·Ralf SchnabelHarald Hutter
Oct 22, 2015·PLoS Genetics·Amanda L ZachariasJohn Isaac Murray
Jun 14, 2016·Developmental Neurobiology·David H Hall
Aug 22, 2021·Seminars in Cell & Developmental Biology·Pedro Gómez-GálvezJavier Buceta

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