Global connectivity of the fronto-parietal cognitive control network is related to depression symptoms in the general population

Network Neuroscience
Douglas H SchultzMichael W Cole

Abstract

We all vary in our mental health, even among people not meeting diagnostic criteria for mental illness. Understanding this individual variability may reveal factors driving the risk for mental illness, as well as factors driving subclinical problems that still adversely affect quality of life. To better understand the large-scale brain network mechanisms underlying this variability, we examined the relationship between mental health symptoms and resting-state functional connectivity patterns in cognitive control systems. One such system is the fronto-parietal cognitive control network (FPN). Changes in FPN connectivity may impact mental health by disrupting the ability to regulate symptoms in a goal-directed manner. Here we test the hypothesis that FPN dysconnectivity relates to mental health symptoms even among individuals who do not meet formal diagnostic criteria but may exhibit meaningful symptom variation. We found that depression symptoms severity negatively correlated with between-network global connectivity (BGC) of the FPN. This suggests that decreased connectivity between the FPN and the rest of the brain is related to increased depression symptoms in the general population. These findings complement previous clinical...Continue Reading

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Citations

Jul 28, 2019·Brain and Behavior·Dazhi YinZheng Wang
Sep 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Kevin M AndersonAvram J Holmes
Jan 10, 2020·Annual Review of Pharmacology and Toxicology·Zhi-De DengSarah H Lisanby
May 30, 2020·Psychological Medicine·Rajpreet ChahalAmanda E Guyer
Oct 20, 2020·Frontiers in Neural Circuits·Sonsoles Alonso MartínezJoana Cabral
Feb 9, 2021·Frontiers in Human Neuroscience·John R Kershner
Apr 10, 2021·Frontiers in Neurology·Eleftherios KavroulakisEfrosini Papadaki
Apr 21, 2021·NeuroImage·Brian P KeaneMichael W Cole
Jun 2, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jiang ZhangJiaojian Wang
Jan 26, 2022·Cerebral Cortex·Douglas H SchultzMichael W Cole

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Software Mentioned

MATLAB
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