Global control of dimorphism and virulence in fungi

Science
Julie C NemecekBruce S Klein

Abstract

Microbial pathogens that normally inhabit our environment can adapt to thrive inside mammalian hosts. There are six dimorphic fungi that cause disease worldwide, which switch from nonpathogenic molds in soil to pathogenic yeast after spores are inhaled and exposed to elevated temperature. Mechanisms that regulate this switch remain obscure. We show that a hybrid histidine kinase senses host signals and triggers the transition from mold to yeast. The kinase also regulates cell-wall integrity, sporulation, and expression of virulence genes in vivo. This global regulator shapes how dimorphic fungal pathogens adapt to the mammalian host, which has broad implications for treating and preventing systemic fungal disease.

References

Jun 1, 1995·Journal of Bacteriology·J M van der VaartC T Verrips
Oct 22, 1993·Science·I M Ota, A Varshavsky
Nov 22, 1997·Cellular and Molecular Life Sciences : CMLS·S White, B Larsen
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·L A AlexM I Simon
Apr 20, 1999·The Journal of Experimental Medicine·T T BrandhorstB Klein
May 26, 1999·Current Biology : CB·J Stock
Jul 2, 1999·Antimicrobial Agents and Chemotherapy·R J DeschenesJ S Fassler
Apr 5, 2003·Cellular Microbiology·Joshua D Nosanchuk, Arturo Casadevall
May 20, 2003·Infectious Disease Clinics of North America·Tom M ChillerDavid A Stevens
Jul 1, 2004·Molecular Microbiology·Chad A RappleyeWilliam E Goldman

❮ Previous
Next ❯

Citations

Mar 5, 2009·Amino Acids·Darío Ortiz de Orué Lucana, Matthew R Groves
Jul 5, 2007·Antonie van Leeuwenhoek·Klara EncziMatthias Sipiczki
Oct 15, 2011·Mycopathologia·Xuying WangJoseph Heitman
Dec 25, 2007·Nature Reviews. Microbiology·Sheryl S JusticeScott J Hultgren
Mar 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Van Q Nguyen, Anita Sil
Sep 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Rachael Hanby Webster, Anita Sil
Jan 9, 2009·Proceedings of the National Academy of Sciences of the United States of America·Robert J Bastidas, Joseph Heitman
Apr 9, 2009·Veterinary Clinical Pathology·Camilo Bulla, Jennifer S Thomas
Nov 30, 2006·Antimicrobial Agents and Chemotherapy·Jeniel NettDavid Andes
Mar 6, 2007·Eukaryotic Cell·Megan L Bohse, Jon P Woods
Sep 18, 2007·Eukaryotic Cell·A George SmulianGeorge S Deepe
Jul 19, 2011·Eukaryotic Cell·Delma S ThompsonDavid Kadosh
May 20, 2009·Infection and Immunity·Steven S GilesChristina M Hull
Sep 4, 2008·Infection and Immunity·Neeraj Chauhan, Richard Calderone
Sep 9, 2006·Microbiology and Molecular Biology Reviews : MMBR·Kevin D Young
Oct 19, 2011·International Journal of Microbiology·Wilber SabiitiE Rhiannon Pursall
Nov 19, 2009·BMC Microbiology·Brian H YouseffChad A Rappleye
Jun 6, 2008·Proteome Science·Julie M ChandlerChester R Cooper

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.