May 20, 2020

Global deficiency of stearoyl-CoA desaturase-2 protects against diet-induced adiposity

Biochemical and Biophysical Research Communications
Lucas M O'NeillJames M Ntambi

Abstract

In mouse, there are four stearoyl-CoA desaturase isoforms (SCD1-4) that catalyze the synthesis of monounsaturated fatty acids. Previously, we have shown that mice harboring a whole body deletion of the SCD1 isoform (SCD1KO) are protected from diet and genetically induced adiposity. Here, we report that global deletion of the SCD2 isoform (SCD2KO) provides a similar protective effect against the onset of both high-fat diet (HFD) and high-carbohydrate diet (HCD) induced adiposity. After 10 weeks of HFD feeding or 6 weeks of HCD feeding, SCD2KO mice failed to gain weight and had decreased fat mass. On HFD, SCD2KO mice remained glucose and insulin tolerant. Lastly, the markers for energy expenditure, UCP1 and PGC-1α, were increased in the brown adipose tissue of HFD fed SCD2KO mice.

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Mentioned in this Paper

Stearoyl-CoA Desaturase
SCD
SCD1 protein, human
Gene Deletion
Brown Fat
brown adipose tissue uncoupling protein
Glucose
Laboratory mice
UCP1
Biological Markers

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