Global Disorders of Sex Development Update since 2006: Perceptions, Approach and Care

Hormone Research in Pædiatrics
Peter A LeeGlobal DSD Update Consortium

Abstract

The goal of this update regarding the diagnosis and care of persons with disorders of sex development (DSDs) is to address changes in the clinical approach since the 2005 Consensus Conference, since knowledge and viewpoints change. An effort was made to include representatives from a broad perspective including support and advocacy groups. The goal of patient care is focused upon the best possible quality of life (QoL). The field of DSD is continuously developing. An update on the clinical evaluation of infants and older individuals with ambiguous genitalia including perceptions regarding male or female assignment is discussed. Topics include biochemical and genetic assessment, the risk of germ cell tumor development, approaches to psychosocial and psychosexual well-being and an update on support groups. Open and on-going communication with patients and parents must involve full disclosure, with the recognition that, while DSD conditions are life-long, enhancement of the best possible outcome improves QoL. The evolution of diagnosis and care continues, while it is still impossible to predict gender development in an individual case with certainty. Such decisions and decisions regarding surgery during infancy that alters externa...Continue Reading

Citations

Feb 22, 2017·LGBT Health·Heino F L Meyer-Bahlburg
Dec 5, 2016·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·Anu Bashamboo, Ken McElreavey
May 26, 2017·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Veronica Gomez-LoboUNKNOWN North American Society for Pediatric and Adolescent Gynecology
May 26, 2017·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Louise C Pyle, Katherine L Nathanson
Jun 3, 2017·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·David E SandbergUNKNOWN DSD-TRN Psychosocial Workgroup, the DSD-TRN Advocacy Advisory Network, and Accord Alliance
Jun 4, 2017·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Margaret P Adam, Eric Vilain
Dec 27, 2016·International Journal of Endocrinology·Georgette Beatriz De PaulaGil Guerra-Junior
Jan 17, 2017·Journal of Pediatric Urology·Ieuan A Hughes
May 13, 2017·Journal of Pediatric Psychology·David E SandbergNina Callens
Feb 27, 2017·The Lancet. Diabetes & Endocrinology·Maayan Sudai
Jan 27, 2018·Human Molecular Genetics·Marie-France PortnoiAnu Bashamboo
Nov 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Agnethe BerglundClaus H Gravholt
May 8, 2018·Journal of Bioethical Inquiry·Morgan Carpenter
Nov 8, 2017·The American Journal of Bioethics : AJOB·Leena Nahata, Gwendolyn P Quinn
Jun 24, 2017·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Jess F PetersonPeter vanTuinen
Oct 2, 2017·Hormone Research in Pædiatrics·Nalini M SelveindranRahmah Rasat
Oct 30, 2018·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·Rafael S YabikuAndréa T Maciel-Guerra
Dec 7, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Rebecca M Harris, Yee-Ming Chan
Oct 28, 2018·Journal of Bioethical Inquiry·Matteo CrestiRoberto Lala
Jul 17, 2018·Endocrine Reviews·David J HandelsmanStephane Bermon
May 7, 2019·Human Mutation·Caroline EozenouRaja Brauner
Jan 13, 2018·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Sam Rowlands, Jean-Jacques Amy
Jun 22, 2019·Sociology of Health & Illness·Stefan TimmermansDavid E Sandberg
Jun 28, 2019·Current Opinion in Pediatrics·Amy B Wisniewski, Amy C Tishelman
Apr 24, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ryan A HekschLeena Nahata
Jun 25, 2019·Psychosomatic Medicine·Annelou L C de VriesUNKNOWN dsd-LIFE Group
Aug 30, 2019·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·Martine van ZoestHedi L Claahsen-van der Grinten
May 31, 2019·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Sarah E SheppardJennifer M Kalish
Jun 1, 2019·International Journal of Pediatric Endocrinology·Michelle M ErnstUNKNOWN DSD-TRN Psychosocial Workgroup and Accord Alliance
Oct 31, 2019·The Journal of Clinical Endocrinology and Metabolism·Saskia van der StraatenMartine Cools
Feb 3, 2020·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·Digumarthi V S SudhakarKumarasamy Thangaraj
Dec 10, 2019·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·Juliana G R AndradeAndrea T Maciel-Guerra
Apr 10, 2020·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·Shan DengQinjie Tian
Apr 3, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Birsen Şentürk PilanŞükran Darcan
May 31, 2019·Nature Reviews. Disease Primers·Andrea SaloniaMario Maggi
Apr 10, 2020·Andrologia·Masomeh AskariMehdi Totonchi
Jan 8, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Guilherme Guaragna-FilhoGil Guerra-Junior
Oct 2, 2019·Cold Spring Harbor Perspectives in Medicine·Andrea Forman, Jilliane Sotelo

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