Global DNA demethylation in gastrointestinal cancer is age dependent and precedes genomic damage

Cancer Cell
Koichi SuzukiManuel Perucho

Abstract

We studied the relationships between genetic and epigenetic alterations in gastrointestinal cancer by integrating DNA copy number changes determined by arbitrarily primed PCR (AP-PCR) with DNA methylation variations estimated by methylation-sensitive amplified fragment length polymorphism (MS-AFLP). We analyzed about 100 different chromosomal regions by AP-PCR and over 150 random CpG loci by MS-AFLP in human colon and gastric carcinomas. DNA hypomethylation and hypermethylation alterations distributed gradually and increased with cancer patient age, in contrast with the age-independent genomic alterations. Increased DNA hypomethylation and hypermethylation correlated with increased genomic damage, but only hypomethylation was highly significant in multivariate analyses. We conclude that age-dependent accumulation of DNA demethylation precedes diploidy loss in a significant subset of gastrointestinal cancers.

References

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M A PeinadoM Perucho
Dec 25, 1990·Nucleic Acids Research·J Welsh, M McClelland
Apr 14, 1989·Science·B VogelsteinR White
Apr 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·A G Knudson
Apr 1, 1981·Cell·M WiglerM Perucho
Jul 16, 1982·Biochemical and Biophysical Research Communications·E S Diala, R M Hoffman
Oct 11, 1983·Nucleic Acids Research·M A Gama-SosaM Ehrlich
Nov 11, 1995·Nucleic Acids Research·P VosM Kuiper
Jan 1, 1994·Cold Spring Harbor Symposia on Quantitative Biology·M PeruchoE Stanbridge
Jun 1, 1995·Genes & Development·J M Bishop
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·C De SmetT Boon
Oct 18, 1996·Cell·K W Kinzler, B Vogelstein
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·S MalkhosyanM Perucho
Feb 12, 1999·Cancer Genetics and Cytogenetics·G Z QuM Ehrlich
Mar 11, 1999·Current Opinion in Genetics & Development·R D Kolodner, G T Marsischky
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·M ToyotaJ P Issa
Dec 10, 1999·Critical Reviews in Oncology/hematology·J P Issa
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Aug 11, 2001·Science·T Jenuwein, C D Allis
Aug 3, 2002·Oncogene·Melanie Ehrlich
Aug 31, 2002·Genes, Chromosomes & Cancer·Wolfgang A SchulzTapio Visakorpi
Oct 2, 2002·Nature Genetics·Giuseppe ZardoJoseph F Costello
Mar 26, 2003·The American Journal of Pathology·Carolyn BariolRobyn Ward
Apr 19, 2003·Science·Amir EdenRudolf Jaenisch
Apr 19, 2003·Science·François GaudetRudolf Jaenisch
Sep 6, 2003·Cancer Cell·Kentaro YamashitaManuel Perucho
Oct 10, 2003·International Journal of Colorectal Disease·Catherine M SuterRobyn L Ward
Dec 9, 2003·Mechanisms of Ageing and Development·Liang LiuTrygve O Tollefsbol
Jan 21, 2004·Nature Reviews. Cancer·Andrew P Feinberg, Benjamin Tycko
Jun 17, 2005·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Michèle J Hoffmann, Wolfgang A Schulz

❮ Previous
Next ❯

Citations

Feb 12, 2008·Journal of Applied Genetics·Paweł KarpińskiNikolaus Blin
Jun 22, 2010·Archives of Gynecology and Obstetrics·Shuping ZhaoChengquan Zhao
Nov 28, 2012·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hironobu ShigakiHideo Baba
Feb 6, 2010·Cancer Metastasis Reviews·Myoung Sook KimDavid Sidransky
Nov 2, 2013·Pathology, Research and Practice·Raimundo F AraújoAurigena Antunes de Araújo
Oct 20, 2011·Nature Reviews. Gastroenterology & Hepatology·Victoria Valinluck Lao, William M Grady
Nov 27, 2008·Journal of the National Cancer Institute·Shuji OginoCharles S Fuchs
Dec 18, 2007·Nucleic Acids Research·Jairo RodriguezMiguel A Peinado
Dec 2, 2010·Current Opinion in Oncology·Nino Sinčić, Zdenko Herceg
Oct 19, 2012·Science Translational Medicine·Hermioni ZouridisPatrick Tan
Dec 3, 2008·Cancer Research·Le JiangBenjamin Tycko
Sep 5, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mary Beth TerryEzra Susser
Sep 25, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Wen-Yi HuangMark P Purdue
Dec 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kiyoshi MisawaThomas E Carey
Sep 11, 2007·Digestive Diseases·Gerardo NardoneAlba Rocco
Apr 21, 2007·American Journal of Respiratory and Critical Care Medicine·Sarita Dubey, Charles A Powell
Aug 26, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shuji OginoCharles S Fuchs
Dec 22, 2011·Annals of Surgical Oncology·Shiro IwagamiHideo Baba
Jul 7, 2012·Annals of Surgical Oncology·Hironobu ShigakiHideo Baba
Dec 30, 2006·PLoS Medicine·Romulo M BrenaJoseph F Costello
May 3, 2011·PloS One·Eiji SunamiDave S B Hoon
Mar 6, 2013·PloS One·Alexander LinkAjay Goel
May 30, 2013·PloS One·Carolina Rosal Teixeira de SouzaRommel Rodríguez Burbano
Dec 1, 2009·Epigenomics·Hector Hernandez-VargasZdenko Herceg
May 25, 2010·Epigenomics·Melanie Ehrlich
Apr 1, 2010·Epigenomics·Jason P RossPeter L Molloy
Dec 14, 2011·International Journal of Oncology·Kei KoizumiKoichi Suzuki
Jun 25, 2013·Pharmacology & Therapeutics·Marc TänzerMichael Quante
Mar 28, 2009·Cellular and Molecular Life Sciences : CMLS·Igor P Pogribny, Frederick A Beland

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.