Global DNA hypomethylation is associated with NTD-affected pregnancy: A case-control study

Birth Defects Research. Part A, Clinical and Molecular Teratology
Xiaoli ChenTing Zhang

Abstract

Neural tube defects are severe, common birth defects that result from failure of neural tube closure. They are considered to be a multifactorial disorder, and our knowledge of causal mechanisms remains limited. We hypothesized that abnormal DNA methylation occurs in NTD-affected fetuses. The correlations of global DNA methylation levels with complexity of NTDs and known risk factors of NTDs, MTHFR genotype and fever, were analyzed. A hospital-based case-control study was performed. Epidemiologic data, pathologic diagnosis, and methylenetetrahydrofolate reductase (MTHFR) genotype analysis were completed. Array comparative genomic hybridization was used to exclude cytogenetic abnormalities. Global DNA methylation statuses were determined for both brain and skin tissue. Sixty-five NTD-affected fetuses and 65 normal controls matched for gestational and maternal ages were collected. In brain tissue, global DNA methylation levels were significantly decreased in cases compared with controls (4.12 vs. 4.99%; p < 0.001). DNA hypomethylation (<4.35%) resulted in a significant 5.736-fold increased risk for NTDs (95% confidence interval, 1.731-19.009; p = 0.004). Nonisolated NTDs had lower levels of global DNA methylation than did isolated...Continue Reading

References

Dec 1, 1976·Archives of Disease in Childhood·R W SmithellsC J Schorah
Dec 24, 1992·The New England Journal of Medicine·A E Czeizel, I Dudás
Sep 11, 1995·American Journal of Medical Genetics·M J Seller
Nov 24, 1999·The New England Journal of Medicine·L D BottoJ D Erickson
Apr 4, 2000·British Medical Bulletin·S J Duthie
May 3, 2000·American Journal of Epidemiology·L D Botto, Q Yang
May 23, 2001·Experimental Biology and Medicine·N M van der PutH J Blom
Aug 11, 2001·Science·W ReikJ Walter
Apr 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Simonetta FrisoJacob Selhub
Jun 11, 2002·Annual Review of Nutrition·Ignatia B Van den Veyver
Aug 7, 2002·The Journal of Nutrition·Richard H FinnellJill S James
Apr 19, 2003·Science·Amir EdenRudolf Jaenisch
Sep 19, 2003·Nature Reviews. Genetics·Andrew J CoppJennifer N Murdoch
Mar 31, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Lijun PeiZhu Li
Apr 1, 2005·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Laura E Mitchell
Jul 6, 2005·Brain Research. Developmental Brain Research·Lydia A AfmanHenny W M van Straaten
Apr 1, 2006·Birth Defects Research. Part A, Clinical and Molecular Teratology·Zhiwen LiZhu Li
Aug 23, 2006·Nature Reviews. Neuroscience·Henk J BlomRichard H Finnell
Aug 31, 2006·Neurogenetics·Patrizia De MarcoValeria Capra
Dec 21, 2006·Birth Defects Research. Part A, Clinical and Molecular Teratology·Muriel J Harris, Diana M Juriloff
Jan 16, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Debra Ting HsiungKarl T Kelsey
Mar 17, 2007·Nature Reviews. Genetics·Randy L Jirtle, Michael K Skinner
Apr 6, 2007·The New England Journal of Medicine·Zoha KibarPhilippe Gros
May 2, 2007·Clinical Genetics·Z KibarP Gros
Aug 31, 2007·Birth Defects Research. Part A, Clinical and Molecular Teratology·Xue GuJufen Liu
Jun 10, 2008·American Journal of Obstetrics and Gynecology·Sonja A RasmussenJoseph Lau
Mar 21, 2009·Prenatal Diagnosis·Martin Cameron, Paul Moran

❮ Previous
Next ❯

Citations

Nov 22, 2011·Journal of Molecular Neuroscience : MN·Susanna TranTing Zhang
May 23, 2012·Nutrition & Metabolism·Sílvia Fernàndez-RoigEdward V Quadros
Feb 8, 2011·PloS One·Shimul ChowdhuryCharlotte A Hobbs
Nov 14, 2013·PloS One·Lisette StolkRégine P M Steegers-Theunissen
Feb 19, 2016·Epigenetics & Chromatin·E Magda PriceWendy P Robinson
Jun 3, 2015·Birth Defects Research. Part A, Clinical and Molecular Teratology·Daniel M WebberCharlotte Hobbs
Jan 22, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Shimul ChowdhuryCharlotte A Hobbs
Jul 19, 2012·Birth Defects Research. Part A, Clinical and Molecular Teratology·Deidre R KruppUNKNOWN National Birth Defects Prevention Study
Jul 15, 2015·Birth Defects Research. Part A, Clinical and Molecular Teratology·Wei MaZhengwei Yuan
Dec 17, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Jinyu ZhengLixin Li
Apr 26, 2012·Epigenetics : Official Journal of the DNA Methylation Society·E Magda PriceWendy Robinson
Jan 8, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Anne RochtusKathleen Freson
Jan 7, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Linlin WangAiguo Ren
Sep 15, 2018·Epigenomics·Huili Li, Lee Niswander
Jul 20, 2012·Neuromolecular Medicine·Ahmed OmranFei Yin
Jun 5, 2019·Oral Diseases·Mohammad Faisal J KhanMichele Rubini
May 7, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Rao Gurugubelli KrishnaPalanivel Chinnakali

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

© 2021 Meta ULC. All rights reserved